Organic reactions in ionic liquids: a simple highly regioselective or regiospecific substitutions of benzotriazole

Le, Zhang-Gao, Chen, Zhen-Chu, Hu, Yi and Zheng, Qinguo (2004). Organic reactions in ionic liquids: a simple highly regioselective or regiospecific substitutions of benzotriazole. Heterocycles, 63 (5), pp. 1077-1081.

Abstract

In the absence of any added base in ionic liquids [Bmim][BF4], benzotriazole replaces the halogen atom of an a-halogenated ketone or a-halogenated carboxylic ester to give the corresponding N-1-substituted benzotriazole as the only isomer, and 1-chloro-2,4-dinitrobenzene reacted similarly with benzotriazole to afford the N-1-substituted benzotriazole in a good yield. Alkyl halides reacted regioselectively to afford the N-1-alkylbenzotriazole in ratios of more than 15 to 1 over the N-2-isomer.

Publication DOI: https://doi.org/10.3987/COM-04-10010
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: ionic liquid,benzotriazole,regioselective,regiospecific
Full Text Link: http://www.hete ... hp?article=1666
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Published Date: 2004-05-01
Authors: Le, Zhang-Gao
Chen, Zhen-Chu
Hu, Yi
Zheng, Qinguo

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