Organic reactions in ionic liquids:A simple and highly regioselective N-substitution of pyrrole

Le, Zhang-Gao, Chen, Zhen-Chu, Hu, Yi and Zheng, Qinguo (2004). Organic reactions in ionic liquids:A simple and highly regioselective N-substitution of pyrrole. Synthesis, 2004 (12), pp. 1951-1954.

Abstract

In ionic liquids [Bmim][PF6] or [Bmim][BF4], pyrrole replaced the halogen atom of an alkyl halide to give the corresponding N-substituted pyrrole in excellent yield. Benzenesulfonyl chloride, p-methylbenzenesulfonyl chloride and benzoyl chloride reacted similarly with pyrroles to afford the N-substituted pyrroles in quantitative yield. Michael addition reaction of pyrrole with electrophilic olefins was completed in a highly regioselective manner to afford the N-alkylpyrroles.

Publication DOI: https://doi.org/10.1055/s-2004-829182
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: acylation,alkylation,ionic liquids,pyrroles,substitution,sulfonylation,Organic Chemistry
Full Text Link: https://www.thi ... 5/s-2004-829182
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2004-08-19
Authors: Le, Zhang-Gao
Chen, Zhen-Chu
Hu, Yi
Zheng, Qinguo

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