Organic reactions in ionic liquids:Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Hu, Yi, Chen, Zhen-Chu, Le, Zhang-Gao and Zheng, Qinguo (2004). Organic reactions in ionic liquids:Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate. Synthetic communications, 34 (20), pp. 3801-3806.

Abstract

Ionic liquids based on 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) and 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2-aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

Publication DOI: https://doi.org/10.1081/SCC-200032526
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: 2-Aminothiophene,Gewald reaction,ionic liquids,knoevenagel condensation,Organic Chemistry
Full Text Link: http://www.info ... e=20&spage=3801
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2004-11-12
Authors: Hu, Yi
Chen, Zhen-Chu
Le, Zhang-Gao
Zheng, Qinguo

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