A general linear model for MEG beamformer imaging

Brookes, Matthew J., Gibson, Andrew M., Hall, Stephen D., Furlong, Paul L., Barnes, Gareth R., Hillebrand, Arjan, Singh, Krish D., Holliday, Ian E., Francis, Sue T. and Morris, Peter G. (2004). A general linear model for MEG beamformer imaging. Neuroimage, 23 (3), pp. 936-946.


A new general linear model (GLM) beamformer method is described for processing magnetoencephalography (MEG) data. A standard nonlinear beamformer is used to determine the time course of neuronal activation for each point in a predefined source space. A Hilbert transform gives the envelope of oscillatory activity at each location in any chosen frequency band (not necessary in the case of sustained (DC) fields), enabling the general linear model to be applied and a volumetric T statistic image to be determined. The new method is illustrated by a two-source simulation (sustained field and 20 Hz) and is shown to provide accurate localization. The method is also shown to locate accurately the increasing and decreasing gamma activities to the temporal and frontal lobes, respectively, in the case of a scintillating scotoma. The new method brings the advantages of the general linear model to the analysis of MEG data and should prove useful for the localization of changing patterns of activity across all frequency ranges including DC (sustained fields). © 2004 Elsevier Inc. All rights reserved.

Publication DOI: https://doi.org/10.1016/j.neuroimage.2004.06.031
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences > Psychology
Life & Health Sciences
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Life & Health Sciences > Optometry
Uncontrolled Keywords: beamformer,cortical oscillatory power,ERD/ERS,general linear model,MEG,scintillating scotoma,spatial filter,Cognitive Neuroscience,Neurology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2004-11
Authors: Brookes, Matthew J.
Gibson, Andrew M.
Hall, Stephen D.
Furlong, Paul L.
Barnes, Gareth R.
Hillebrand, Arjan
Singh, Krish D.
Holliday, Ian E.
Francis, Sue T.
Morris, Peter G.


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