Thiosemicarbazones active against Clostridium difficile

Costello, Cait, Karpanen, Tarja, Lambert, Peter A., Mistry, Preena, Parker, Katy J., Rathbone, Daniel L., Ren, Jiangmeng, Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711.

Abstract

A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.

Publication DOI: https://doi.org/10.1016/j.bmcl.2008.01.041
Divisions: Life & Health Sciences
Life & Health Sciences > Biosciences
Life & Health Sciences > Pharmacy
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711. DOI 10.1016/j.bmcl.2008.01.041
Uncontrolled Keywords: thiosemicarbazone,Clostridium difficile,antimicrobial,nitrofuran,Biochemistry,Molecular Biology,Organic Chemistry,Drug Discovery,Pharmaceutical Science
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2008-03-01
Authors: Costello, Cait
Karpanen, Tarja
Lambert, Peter A. ( 0000-0002-8243-2741)
Mistry, Preena
Parker, Katy J.
Rathbone, Daniel L. ( 0000-0003-4732-4662)
Ren, Jiangmeng
Wheeldon, Laura
Worthington, Tony ( 0000-0002-1906-3357)

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