Limitations of the isolated GP-STN network

Stanford, Ian M., Loucif, K.C., Wilson, Clare L., Cash, D. and Lacey, M.G. (2005). Limitations of the isolated GP-STN network. IN: The Basal Ganglia VIII. Bolam, J.P.; Ingham, C.A. and Magill, P.J. (eds) Advances in Behavioral Biology, 8 . New York (US): Springer.

Abstract

An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.

Publication DOI: https://doi.org/10.1007/0-387-28066-9_6
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
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Additional Information: 8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004
Event Title: Basal Ganglia VIII
Event Type: Other
Event Dates: 2005-12-25 - 2005-12-25
Full Text Link: http://www.spri ... cead144484&pi=5
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Published Date: 2005-12-25
Authors: Stanford, Ian M. ( 0000-0002-5677-8538)
Loucif, K.C.
Wilson, Clare L.
Cash, D.
Lacey, M.G.

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