IMI - Clinical Myopia Control Trials and Instrumentation Report

Wolffsohn, James S, Kollbaum, Pete S, Berntsen, David A, Atchison, David A, Benavente, Alexandra, Bradley, Arthur, Buckhurst, Hetal, Collins, Michael, Fujikado, Takashi, Hiraoka, Takahiro, Hirota, Masakazu, Jones, Debbie, Logan, Nicola S, Lundström, Linda, Torii, Hidemasa, Read, Scott A and Naidoo, Kovin (2019). IMI - Clinical Myopia Control Trials and Instrumentation Report. Investigative Ophthalmology and Visual Science, 60 (3), M132-M160.

Abstract

The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes were classified as primary (refractive error and/or axial length), secondary (patient reported outcomes and treatment compliance), and exploratory (peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently available instrumentation, which the literature has shown to best achieve the primary and secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient selection were also identified. These findings and consensus from the International Myopia Institute members led to final recommendations to inform future instrumentation development and to guide clinical trial protocols.

Publication DOI: https://doi.org/10.1167/iovs.18-25955
Divisions: Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Optometry
Additional Information: Copyright 2019 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Uncontrolled Keywords: Clinical trial guidelines,Instrumentation,Myopia control,Myopia progression,Recommendations,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
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Related URLs: https://iovs.ar ... ticleid=2727316 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2019-02-28
Authors: Wolffsohn, James S ( 0000-0003-4673-8927)
Kollbaum, Pete S
Berntsen, David A
Atchison, David A
Benavente, Alexandra
Bradley, Arthur
Buckhurst, Hetal
Collins, Michael
Fujikado, Takashi
Hiraoka, Takahiro
Hirota, Masakazu
Jones, Debbie
Logan, Nicola S ( 0000-0002-0538-9516)
Lundström, Linda
Torii, Hidemasa
Read, Scott A
Naidoo, Kovin

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