Role of inhibitory feedback for information processing in thalamocortical circuits

Mayer, Jörg, Schuster, Heinz Georg and Claussen, Jens Christian (2006). Role of inhibitory feedback for information processing in thalamocortical circuits. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 73 (3),

Abstract

The information transfer in the thalamus is blocked dynamically during sleep, in conjunction with the occurrence of spindle waves. In order to describe the dynamic mechanisms which control the sensory transfer of information, it is necessary to have a qualitative model for the response properties of thalamic neurons. As the theoretical understanding of the mechanism remains incomplete, we analyze two modeling approaches for a recent experiment by Le Masson [Nature (London) 417, 854 (2002)] on the thalamocortical loop. We use a conductance based model in order to motivate an extension of the Hindmarsh-Rose model, which mimics experimental observations of Le Masson Typically, thalamic neurons posses two different firing modes, depending on their membrane potential. At depolarized potentials, the cells fire in a single spike mode and relay synaptic inputs in a one-to-one manner to the cortex. If the cell gets hyperpolarized, T -type calcium currents generate burst-mode firing which leads to a decrease in the spike transfer. In thalamocortical circuits, the cell membrane gets hyperpolarized by recurrent inhibitory feedback loops. In the case of reciprocally coupled excitatory and inhibitory neurons, inhibitory feedback leads to metastable self-sustained oscillations, which mask the incoming input, and thereby reduce the information transfer significantly.

Publication DOI: https://doi.org/10.1103/PhysRevE.73.031908
Divisions: Engineering & Applied Sciences
Additional Information: ©2006 American Physical Societ. Role of inhibitory feedback for information processing in thalamocortical circuit. Jörg Mayer, Heinz Georg Schuster, and Jens Christian Claussen Phys. Rev. E 73, 031908 – Published 13 March 2006
Uncontrolled Keywords: Statistical and Nonlinear Physics,Statistics and Probability,Condensed Matter Physics
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://journal ... sRevE.73.031908 (Publisher URL)
Published Date: 2006-03-20
Authors: Mayer, Jörg
Schuster, Heinz Georg
Claussen, Jens Christian ( 0000-0002-9870-4924)

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