Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease

Arora, Siddharth, Visanji, Naomi P., Mestre, Tiago A., Tsanas, Athanasios, AlDakheel, Amaal, Connolly, Barbara S., Gasca-Salas, Carmen, Kern, Drew S., Jain, Jennifer, Slow, Elizabeth J., Faust-Socher, Achinoam, Lang, Anthony E., Little, Max A. and Marras, Connie (2018). Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease. Journal of Parkinson's Disease, 8 (4), pp. 503-510.

Abstract

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

Publication DOI: https://doi.org/10.3233/JPD-181389
Divisions: Engineering & Applied Sciences > Mathematics
Engineering & Applied Sciences > Systems analytics research institute (SARI)
Additional Information: ©2018 IOS Press.
Uncontrolled Keywords: biomarker,LRRK2 mutation,Parkinson’s disease,voice,Clinical Neurology,Cellular and Molecular Neuroscience
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://content ... sease/jpd181389 (Publisher URL)
Published Date: 2018-10-17
Authors: Arora, Siddharth
Visanji, Naomi P.
Mestre, Tiago A.
Tsanas, Athanasios
AlDakheel, Amaal
Connolly, Barbara S.
Gasca-Salas, Carmen
Kern, Drew S.
Jain, Jennifer
Slow, Elizabeth J.
Faust-Socher, Achinoam
Lang, Anthony E.
Little, Max A. ( 0000-0002-1507-3822)
Marras, Connie

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