Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice

Watkins, Adam J., Dias, Irundika, Tsuro, Heather, Allen, Danielle, Emes, Richard D., Moreton, Joanna, Wilson, Ray, Ingram, Richard J. M. and Sinclair, Kevin D. (2018). Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice. Proceedings of the National Academy of Sciences, 115 (40), pp. 10064-10069.

Abstract

Parental health and diet at the time of conception determine the development and life-long disease risk of their offspring. While the association between poor maternal diet and offspring health is well established, the underlying mechanisms linking paternal diet with offspring health are poorly defined. Possible programming pathways include changes in testicular and sperm epigenetic regulation and status, seminal plasma composition, and maternal reproductive tract responses regulating early embryo development. In this study, we demonstrate that paternal low-protein diet induces sperm-DNA hypomethylation in conjunction with blunted female reproductive tract embryotrophic, immunological, and vascular remodeling responses. Furthermore, we identify sperm- and seminal plasma-specific programming effects of paternal diet with elevated offspring adiposity, metabolic dysfunction, and altered gut microbiota.

Publication DOI: https://doi.org/10.1073/pnas.1806333115
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences > Psychology
Life & Health Sciences
Additional Information: Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
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Related URLs: http://www.pnas ... pnas.1806333115 (Publisher URL)
Published Date: 2018-10-02
Authors: Watkins, Adam J.
Dias, Irundika ( 0000-0002-6620-8221)
Tsuro, Heather
Allen, Danielle
Emes, Richard D.
Moreton, Joanna
Wilson, Ray
Ingram, Richard J. M.
Sinclair, Kevin D.

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