Noninvasive control of rhodamine-loaded capsules distribution in vivo

Stelmashchuk, Olga, Tarakanchikova, Y, Seryogina, E, Piavchenko, G, Zherebtsov, Evgeny, Dunaev, Andrey V., Popov, A and Meglinski, Igor (2018). Noninvasive control of rhodamine-loaded capsules distribution in vivo. IN: Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX. Proceedings of SPIE, 10716 . SPIE.

Abstract

Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

Publication DOI: https://doi.org/10.1117/12.2315773
Divisions: Engineering & Applied Sciences
Engineering & Applied Sciences > Institute of Photonics
Additional Information: Copyright 2018 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Event Title: Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Event Type: Other
Event Dates: 2017-09-26 - 2017-09-30
Full Text Link:
Related URLs: https://www.spi ... 5773.full?SSO=1 (Publisher URL)
Published Date: 2018-04-26
Authors: Stelmashchuk, Olga
Tarakanchikova, Y
Seryogina, E
Piavchenko, G
Zherebtsov, Evgeny ( 0000-0002-3635-1430)
Dunaev, Andrey V.
Popov, A
Meglinski, Igor

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