Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus

Joshi, Sameer, Chaudhari, Atul A, Dennis, Vida, Kirby, Daniel J, Perrie, Yvonne and Singh, Shree Ram (2018). Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus. Bioengineering (Basel, Switzerland), 5 (2),

Abstract

Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.

Publication DOI: https://doi.org/10.3390/bioengineering5020037
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences > Biosciences
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: liposomes, respiratory syncytial viru,peptide,hydrophilic
Full Text Link:
Related URLs: http://www.mdpi ... 306-5354/5/2/37 (Publisher URL)
Published Date: 2018-05-09
Authors: Joshi, Sameer
Chaudhari, Atul A
Dennis, Vida
Kirby, Daniel J ( 0000-0002-0878-2620)
Perrie, Yvonne
Singh, Shree Ram

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