Response of the Aging Eye to First Day of Modern Material Contact Lens Wear

Lafosse, Edouard, Martínez-albert, Noelia, Wolffsohn, James S. W., Cerviño, Alejandro and García-lázaro, Santiago (2018). Response of the Aging Eye to First Day of Modern Material Contact Lens Wear. Eye and Contact Lens ,


Objectives: To investigate the ocular surface of an aged population wearing a daily disposable contact lens (CL) over their 1st day of wear. Methods: Forty eyes from 40 presbyopic subjects were fitted a daily CL (Delefilcon A). Tear osmolarity, tear meniscus area (TMA), and ocular surface aberrations (total higher-order root mean square [RMS]) were assessed at baseline (t0), at 20 min (t1) and after 8 hr (t2) of wear. Fluorescein corneal and conjunctival staining and tear breakup time (TBUT) were performed at t0 and t2. Results: No statistically significant changes were found between t0, t1, and t2 for TMA and between t0 and t2 for fluorescein corneal and conjunctival staining. Tear breakup time worsened by the end of the day from 10.460.4 sec t0 to 9.060.3 sec t2 (P,0.05). Osmolarity showed significant changes between t0 306.962.3 mOsm/L and t1 312.462.4 mOsmol/L (P¼0.02) but returned to baseline values at 8 hr (310.4062.26 mOsm/L; P¼0.09). Total higher-order RMS showed significant changes between t0 0.3860.02 mm and t1 0.6160.04 mm (P#0.001) and between t0 and t2 0.6460.41 mm (P#0.001). Conclusions: Delefilcon A may induce measures changes (osmolarity and TBUT values) in a presbyopic population; however, TMA and vital staining were maintained at the baseline level over the day

Publication DOI:
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Aston University (General)
Additional Information: This is the accepted version of the following article: Response of the Aging Eye to First Day of Modern Material Contact Lens Wear. Lafosse, Edouard, M.Sc.; Martínez-Albert, Noelia, M.Sc.; Wolffsohn, James S. W., Ph.D.; Cerviño, Alejandro, Ph.D.; García-Lázaro, Santiago, Ph.D. Eye & Contact Lens: June 25, 2018 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/ICL.0000000000000514 Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie SklodowskaCurie grant agreement No. 642760 EDEN ITN-EJD Project Horizon 2020 and “Atracció de Talent” research scholarship UV-INVPREDOC16F1-385061 (University of Valencia) awarded to Noelia Martínez.
Full Text Link:
Related URLs: http://Insights ... 900000000-99237 (Publisher URL)
Published Online Date: 2018-06-25
Authors: Lafosse, Edouard
Martínez-albert, Noelia
Wolffsohn, James S. W. ( 0000-0003-4673-8927)
Cerviño, Alejandro
García-lázaro, Santiago


Item under embargo.

Export / Share Citation


Additional statistics for this record