A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation

Schellenberger Costa, Michael, Weigenand, Arne, Ngo, Hong Viet V., Marshall, Lisa, Born, Jan, Martinetz, Thomas and Claussen, Jens Christian (2016). A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS computational biology, 12 (9),

Abstract

Few models exist that accurately reproduce the complex rhythms of the thalamocortical system that are apparent in measured scalp EEG and at the same time, are suitable for large-scale simulations of brain activity. Here, we present a neural mass model of the thalamocortical system during natural non-REM sleep, which is able to generate fast sleep spindles (12–15 Hz), slow oscillations (<1 Hz) and K-complexes, as well as their distinct temporal relations, and response to auditory stimuli. We show that with the inclusion of detailed calcium currents, the thalamic neural mass model is able to generate different firing modes, and validate the model with EEG-data from a recent sleep study in humans, where closed-loop auditory stimulation was applied. The model output relates directly to the EEG, which makes it a useful basis to develop new stimulation protocols.

Publication DOI: https://doi.org/10.1371/journal.pcbi.1005022
Divisions: Engineering & Applied Sciences
Additional Information: © 2016 Schellenberger Costa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords: Ecology, Evolution, Behavior and Systematics,Modelling and Simulation,Ecology,Molecular Biology,Genetics,Cellular and Molecular Neuroscience,Computational Theory and Mathematics
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2016-09-01
Authors: Schellenberger Costa, Michael
Weigenand, Arne
Ngo, Hong Viet V.
Marshall, Lisa
Born, Jan
Martinetz, Thomas
Claussen, Jens Christian ( 0000-0002-9870-4924)

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