In silico prediction of cancer immunogens:current state of the art

Doytchinova, Irini A. and Flower, Darren R. (2018). In silico prediction of cancer immunogens:current state of the art. Immunology, 19 (1),

Abstract

Cancer kills 8 million annually worldwide. Although survival rates in prevalent cancers continue to increase, many cancers have no effective treatment, prompting the search for new and improved protocols. Immunotherapy is a new and exciting addition to the anti-cancer arsenal. The successful and accurate identification of aberrant host proteins acting as antigens for vaccination and immunotherapy is a key aspiration for both experimental and computational research. Here we describe key elements of in silico prediction, including databases of cancer antigens and bleeding-edge methodology for their prediction. We also highlight the role dendritic cell vaccines can play and how they can act as delivery mechanisms for epitope ensemble vaccines. Immunoinformatics can help streamline the discovery and utility of Cancer Immunogens.

Publication DOI: https://doi.org/10.1186/s12865-018-0248-x
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: Copyright: The Authors This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Funding: Aston University, the National Science Fund, Bulgaria, and the Medical Research Council of the Medical University of Sofia, Bulgaria.
Uncontrolled Keywords: Cancer immunogens,Databases of cancer immunogens,Prediction of cancer immunogens,Dendritic cell-based vaccines,Multi-epitope vaccines
Full Text Link: https://bmcimmu ... 2865-018-0248-x
Related URLs: https://bmcimmu ... 2865-018-0248-x (Publisher URL)
Published Date: 2018-03-15
Authors: Doytchinova, Irini A.
Flower, Darren R. ( 0000-0002-8542-7067)

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