The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia

Denny, Brian J., Lambert, Peter A. and West, Patrick W J (2002). The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia. FEMS Microbiology Letters, 208 (1), pp. 21-24.

Abstract

The flavonoid galangin inhibits the partially purified metallo-β-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl2 suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.

Publication DOI: https://doi.org/10.1016/S0378-1097(01)00580-8
Divisions: Life & Health Sciences
Life & Health Sciences > Biosciences
Uncontrolled Keywords: Flavonoid,Galangin,Metallo-β-lactamase,Molecular modelling,Stenotrophomonas maltophilia,Genetics,Molecular Biology,Applied Microbiology and Biotechnology,Microbiology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2002-02-19
Authors: Denny, Brian J.
Lambert, Peter A. ( 0000-0002-8243-2741)
West, Patrick W J

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