Distinct Fermentation and Antibiotic Sensitivity Profiles Exist in Salmonellae of Canine and Human Origin

Wallis, Corrin, Lowden, Preena, Marshall-Jones, Zoe and Hilton, Anthony C (2018). Distinct Fermentation and Antibiotic Sensitivity Profiles Exist in Salmonellae of Canine and Human Origin. BMC Microbiology, 18 ,

Abstract

Background Salmonella enterica is a recognised cause of diarrhoea in dogs and humans, yet the potential for transfer of salmonellosis between dogs and their owners is unclear, with reported evidence both for and against Salmonella as a zoonotic pathogen. A collection of 174 S. enterica isolates from clinical infections in humans and dogs were analysed for serotype distribution, carbon source utilisation, chemical and antimicrobial sensitivity profiles. The aim of the study was to understand the degree of conservation in phenotypic characteristics of isolates across host species. Results Serovar distribution across human and canine isolates demonstrated nine serovars common to both host species, 24 serovars present in only the canine collection and 39 solely represented within the human collection. Significant differences in carbon source utilisation profiles and ampicillin, amoxicillin and chloramphenicol sensitivity profiles were detected in isolates of human and canine origin. Differences between the human and canine Salmonella collections were suggestive of evolutionary separation, with canine isolates better able to utilise several simple sugars than their human counterparts. Generally higher minimum inhibitory concentrations of three broad-spectrum antimicrobials, commonly used in veterinary medicine, were also observed in canine S. enterica isolates. Conclusions Differential carbon source utilisation and antimicrobial sensitivity profiles in pathogenic Salmonella isolated from humans and dogs are suggestive of distinct reservoirs of infection for these hosts. Although these findings do not preclude zoonotic or anthroponotic potential in salmonellae, the separation of carbon utilisation and antibiotic profiles with isolate source is indicative that infectious isolates are not part of a common reservoir shared frequently between these host species.

Publication DOI: https://doi.org/10.1186/s12866-018-1153-4
Divisions: Life & Health Sciences
Life & Health Sciences > Biosciences
Additional Information: © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Funding: (BBSRC) CASE studentship
Uncontrolled Keywords: Salmonella,dog,canine,human,zonnosis,anthroponosis,BIOLOG,antibiotic
Published Date: 2018-02-26
Authors: Wallis, Corrin
Lowden, Preena
Marshall-Jones, Zoe
Hilton, Anthony C ( 0000-0001-8025-5270)

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