%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Ana Lígia Silva de Lima, Tim Hahn, Luc J. W. Evers, Nienke M. de Vries, Eli Cohen, Michal Afek, Lauren Bataille, Margaret Daeschler, Kasper Claes, Babak Boroojerdi, Dolors Terricabras, Max A. Little, Heribert Baldus, Bastiaan R. Bloem, Marjan J. Faber
Feasibility of large-scale deployment of multiple wearable sensors in Parkinson's disease
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 15 0 R/Contents 16 0 R/TrimBox[0 0 612 792]>>
endobj
15 0 obj
[17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref001)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref002)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref003)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref004)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref005)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref006)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref007)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref008)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref009)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref018)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref019)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref009)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref013)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref017)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref018)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.t001)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref020)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref021)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref022)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref023)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref024)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0189161.ref025)>>
endobj
41 0 obj
<>/Border[0 0 0]/A 53 0 R>>
endobj
53 0 obj
<>
endobj
42 0 obj
<>/Border[0 0 0]/A 54 0 R>>
endobj
54 0 obj
<>
endobj
43 0 obj
<>/Border[0 0 0]/A 55 0 R>>
endobj
55 0 obj
<>
endobj
44 0 obj
<>/Border[0 0 0]/A 56 0 R>>
endobj
56 0 obj
<>
endobj
45 0 obj
<>/Border[0 0 0]/A 57 0 R>>
endobj
57 0 obj
<>
endobj
46 0 obj
<>/Border[0 0 0]/A 58 0 R>>
endobj
58 0 obj
<>
endobj
47 0 obj
<>/Border[0 0 0]/A 59 0 R>>
endobj
59 0 obj
<>
endobj
48 0 obj
<>/Border[0 0 0]/A 60 0 R>>
endobj
60 0 obj
<>
endobj
49 0 obj
<>/Border[0 0 0]/A 61 0 R>>
endobj
61 0 obj
<>
endobj
50 0 obj
<>/Border[0 0 0]/A 62 0 R>>
endobj
62 0 obj
<>
endobj
51 0 obj
<>/Border[0 0 0]/A 63 0 R>>
endobj
63 0 obj
<>
endobj
52 0 obj
<>/Border[0 0 0]/A 64 0 R>>
endobj
64 0 obj
<>
endobj
16 0 obj
[65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R]
endobj
65 0 obj
<>stream
q
0.83 0.64 0.02 0 k
356.7118 674.9858 m
361.474 674.9858 l
h
f*
554.7402 662.0031 m
559.5024 662.0031 l
h
f*
563.9244 662.0031 m
568.6866 662.0031 l
h
f*
393.1654 635.9811 m
397.9276 635.9811 l
h
f*
348.1512 610.0157 m
352.8567 610.0157 l
h
f*
357.3354 610.0157 m
362.0976 610.0157 l
h
f*
238.2236 571.011 m
242.9291 571.011 l
h
f*
421.5685 558.0283 m
426.3307 558.0283 l
h
f*
306.085 519.0236 m
310.8472 519.0236 l
h
f*
316.063 519.0236 m
325.5307 519.0236 l
h
f*
242.1354 493.0016 m
251.6598 493.0016 l
h
f*
256.8189 493.0016 m
266.3433 493.0016 l
h
f*
491.5276 466.9795 m
501.052 466.9795 l
h
f*
240.4913 389.0268 m
245.2535 389.0268 l
h
f*
249.6756 389.0268 m
259.2 389.0268 l
h
f*
263.6787 389.0268 m
273.1465 389.0268 l
h
f*
277.6252 389.0268 m
287.1496 389.0268 l
h
f*
293.6693 254.948 m
322.8094 254.948 l
h
f*
244.5165 198.9354 m
253.9843 198.9354 l
h
f*
361.1339 120.926 m
370.6583 120.926 l
h
f*
524.6929 120.926 m
534.2173 120.926 l
h
f*
366.8598 107.9433 m
376.3843 107.9433 l
h
f*
302.7402 94.9039 m
312.2079 94.9039 l
h
f*
409.5496 81.9213 m
419.074 81.9213 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Parkinson's)Tj
4.8812 0 Td
(Disease)Tj
3.2201 0 Td
(\(PD\))Tj
2.1883 0 Td
(is)Tj
0.8391 0 Td
(a)Tj
0.6463 0 Td
(common)Tj
3.8381 0 Td
(neurodegenerative)Tj
7.6535 0 Td
(disease)Tj
3.0103 0 Td
(in)Tj
1.0262 0 Td
(which)Tj
2.6419 0 Td
(patients)Tj
3.3618 0 Td
(experience)Tj
-33.3068 -1.3039 Td
(both)Tj
2.0579 0 Td
(motor)Tj
2.7212 0 Td
(and)Tj
1.7348 0 Td
(non-motor)Tj
4.6772 0 Td
(symptoms[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
5.7372 0 Td
(Treatment)Tj
4.4504 0 Td
(is)Tj
0.8447 0 Td
(primarily)Tj
3.9742 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(management)Tj
-31.4133 -1.2982 Td
(of)Tj
1.0147 0 Td
(symptoms)Tj
4.3597 0 Td
(by)Tj
1.1792 0 Td
(increasing)Tj
4.3313 0 Td
(dopamine)Tj
4.2633 0 Td
(levels)Tj
2.3754 0 Td
(through)Tj
3.4469 0 Td
(pharmacological)Tj
6.8428 0 Td
(therapy)Tj
3.2428 0 Td
(or)Tj
1.0999 0 Td
(surgery[)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.2349 0 Td
(3)Tj
0 g
(].)Tj
-36.3909 -1.2983 Td
(Additionally,)Tj
5.4538 0 Td
(non-pharmacological)Tj
8.7987 0 Td
(therapies,)Tj
4.0648 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(physiotherapy,)Tj
6.1058 0 Td
(occupational)Tj
5.3518 0 Td
(therapy)Tj
3.2485 0 Td
(or)Tj
-36.1018 -1.3039 Td
(speech)Tj
2.8969 0 Td
(therapy,)Tj
3.4696 0 Td
(are)Tj
1.4514 0 Td
(available)Tj
3.6623 0 Td
(to)Tj
1.0261 0 Td
(support)Tj
3.3222 0 Td
(patients[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
-14.6323 -1.2983 Td
(Although)Tj
4.0081 0 Td
(good)Tj
2.2224 0 Td
(results)Tj
2.8119 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(management)Tj
5.4369 0 Td
(of)Tj
1.0147 0 Td
(motor)Tj
2.7213 0 Td
(symptoms)Tj
4.3596 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.1203 0 Td
(achieved,)Tj
3.9288 0 Td
(particu-)Tj
-34.384 -1.2982 Td
(larly)Tj
1.9729 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(early)Tj
2.1486 0 Td
(stages)Tj
2.5625 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(disease[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.0592 0 Td
(6)Tj
0 g
(],)Tj
1.2586 0 Td
(two)Tj
1.7121 0 Td
(major)Tj
2.6079 0 Td
(problems)Tj
3.9741 0 Td
(hamper)Tj
3.3109 0 Td
(long-term)Tj
4.2519 0 Td
(treatment.)Tj
-32.8476 -1.304 Td
(First,)Tj
2.2677 0 Td
(current)Tj
3.1861 0 Td
(pharmacological)Tj
6.8428 0 Td
(therapy)Tj
3.2484 0 Td
(is)Tj
0.8448 0 Td
(successful)Tj
4.1669 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6576 0 Td
(limited)Tj
3.0671 0 Td
(period.)Tj
3.0614 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(long)Tj
1.9842 0 Td
(term,)Tj
-33.2898 -1.2982 Td
(most)Tj
2.2053 0 Td
(patients)Tj
3.3675 0 Td
(develop)Tj
3.3222 0 Td
(unmanageable)Tj
6.0321 0 Td
(motor)Tj
2.7212 0 Td
(complications)Tj
5.8394 0 Td
(that)Tj
1.7801 0 Td
(can)Tj
1.6214 0 Td
(lead)Tj
1.8539 0 Td
(to)Tj
1.0261 0 Td
(worsening)Tj
4.3937 0 Td
(of)Tj
1.0148 0 Td
(qual-)Tj
-35.1777 -1.2983 Td
(ity)Tj
1.2415 0 Td
(of)Tj
1.0148 0 Td
(life[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
2.8233 0 Td
(Second,)Tj
3.3505 0 Td
(evaluation)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(day-to-day)Tj
4.5637 0 Td
(variations)Tj
4.1613 0 Td
(in)Tj
1.0374 0 Td
(PD)Tj
1.5137 0 Td
(symptoms)Tj
4.3597 0 Td
(is)Tj
0.8447 0 Td
(difficult)Tj
3.3562 0 Td
(when)Tj
-33.6413 -1.2983 Td
(relying)Tj
2.9933 0 Td
(solely)Tj
2.4605 0 Td
(upon)Tj
2.3187 0 Td
(periodic)Tj
3.5263 0 Td
(consultations)Tj
5.5502 0 Td
(by)Tj
1.1792 0 Td
(clinicians[)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
5.3858 0 Td
(Therefore,)Tj
4.3936 0 Td
(more)Tj
2.3415 0 Td
(detailed,)Tj
3.5943 0 Td
(objective)Tj
-33.7434 -1.3039 Td
(and)Tj
1.7291 0 Td
(reliable)Tj
3.1407 0 Td
(measures)Tj
3.9402 0 Td
(during)Tj
2.9253 0 Td
(daily)Tj
2.1487 0 Td
(living)Tj
2.4718 0 Td
(could)Tj
2.4547 0 Td
(potentially)Tj
4.4561 0 Td
(improve)Tj
3.5829 0 Td
(the)Tj
1.4684 0 Td
(management)Tj
5.4368 0 Td
(of)Tj
1.0148 0 Td
(PD.)Tj
-33.5733 -1.2982 Td
(Wearable)Tj
4.0251 0 Td
(sensors)Tj
3.1578 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1204 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5171 0 Td
(PD-related)Tj
4.5921 0 Td
(symptoms)Tj
4.3597 0 Td
(continuously)Tj
5.4368 0 Td
(and)Tj
1.7291 0 Td
(longitu-)Tj
-34.2819 -1.2983 Td
(dinally)Tj
2.9423 0 Td
(during)Tj
2.931 0 Td
(daily)Tj
2.1486 0 Td
(living[)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
5.3178 0 Td
(Wearables)Tj
4.388 0 Td
(may)Tj
1.9276 0 Td
(provide)Tj
3.2881 0 Td
(greater)Tj
3.0047 0 Td
(insight)Tj
2.9537 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.6577 0 Td
(patient's)Tj
-31.402 -1.3039 Td
(disease)Tj
3.016 0 Td
(status,)Tj
2.7269 0 Td
(allowing)Tj
3.617 0 Td
(patients)Tj
3.3675 0 Td
(to)Tj
1.0262 0 Td
(self-manage)Tj
5.0116 0 Td
(their)Tj
2.1089 0 Td
(symptoms)Tj
4.3597 0 Td
(and)Tj
1.7291 0 Td
(monitor)Tj
3.5433 0 Td
(medication)Tj
-30.5062 -1.2983 Td
(responses[)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
7.4153 0 Td
(Furthermore,)Tj
5.6183 0 Td
(wearable)Tj
3.7417 0 Td
(sensor)Tj
2.7949 0 Td
(data)Tj
1.9106 0 Td
(may)Tj
1.9275 0 Td
(improve)Tj
3.583 0 Td
(our)Tj
1.6271 0 Td
(scientific)Tj
3.787 0 Td
(understand-)Tj
-32.4054 -1.2982 Td
(ing)Tj
1.5023 0 Td
(of)Tj
1.0148 0 Td
(disease)Tj
3.016 0 Td
(progression)Tj
4.921 0 Td
(by)Tj
1.1792 0 Td
(showing)Tj
3.5829 0 Td
(changes)Tj
3.4016 0 Td
(in)Tj
1.0375 0 Td
(motor)Tj
2.7212 0 Td
(and)Tj
1.7291 0 Td
(non-motor)Tj
4.6772 0 Td
(symptoms)Tj
4.3596 0 Td
(over)Tj
1.9786 0 Td
(time,)Tj
-35.121 -1.304 Td
(furthering)Tj
4.3086 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(digital)Tj
2.7269 0 Td
(biomarkers)Tj
4.7792 0 Td
(for)Tj
1.3833 0 Td
(disease)Tj
3.0217 0 Td
(progression[)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
-22.9151 -1.2982 Td
(While)Tj
2.6532 0 Td
(the)Tj
1.4683 0 Td
(potential)Tj
3.7587 0 Td
(value)Tj
2.3074 0 Td
(of)Tj
1.0148 0 Td
(wearable)Tj
3.7474 0 Td
(sensors)Tj
3.1521 0 Td
(for)Tj
1.3833 0 Td
(disease)Tj
3.016 0 Td
(management)Tj
5.4369 0 Td
(and)Tj
1.7291 0 Td
(research)Tj
3.5603 0 Td
(are)Tj
-34.4237 -1.2983 Td
(increasingly)Tj
5.0286 0 Td
(becoming)Tj
4.1839 0 Td
(clear,)Tj
2.3414 0 Td
(various)Tj
3.1408 0 Td
(critical)Tj
2.9536 0 Td
(aspects)Tj
3.0388 0 Td
(of)Tj
1.0148 0 Td
(feasibility)Tj
4.0308 0 Td
(remain)Tj
3.0897 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1509 0 Td
(determined.)Tj
-30.9938 -1.2983 Td
(Only)Tj
2.2166 0 Td
(a)Tj
0.652 0 Td
(few)Tj
1.6157 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.058 0 Td
(rigorously)Tj
4.2973 0 Td
(investigated)Tj
4.9889 0 Td
(the)Tj
1.474 0 Td
(feasibility)Tj
4.0309 0 Td
(and)Tj
1.7291 0 Td
(acceptability)Tj
5.2157 0 Td
(of)Tj
1.0148 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(wear-)Tj
-35.3251 -1.3039 Td
(able)Tj
1.8311 0 Td
(platform)Tj
3.702 0 Td
(comprising)Tj
4.7679 0 Td
(a)Tj
0.652 0 Td
(smartphone)Tj
5.0286 0 Td
(in)Tj
1.0375 0 Td
(combination)Tj
5.3461 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(smartwatch.)Tj
5.0966 0 Td
(Moreover,)Tj
4.3994 0 Td
(these)Tj
-33.5393 -1.2982 Td
(prior)Tj
2.2506 0 Td
(findings)Tj
3.498 0 Td
(remained)Tj
4.0308 0 Td
(limited)Tj
3.0728 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(small)Tj
2.3301 0 Td
(sample)Tj
3.0217 0 Td
(sizes)Tj
2.0466 0 Td
(\(biggest)Tj
3.3448 0 Td
(sample)Tj
3.0217 0 Td
(thus)Tj
1.9333 0 Td
(far:)Tj
1.542 0 Td
(40)Tj
1.1679 0 Td
(PD)Tj
-33.9078 -1.2983 Td
(patients\))Tj
3.7076 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3947 0 Td
(18)Tj
0 g
(].)Tj
1.7348 0 Td
(Therefore,)Tj
4.3936 0 Td
(we)Tj
1.3266 0 Td
(aimed)Tj
2.6929 0 Td
(to)Tj
1.0262 0 Td
(investigate)Tj
4.4617 0 Td
(the)Tj
1.4683 0 Td
(feasibility)Tj
4.0365 0 Td
(of)Tj
1.0148 0 Td
(using)Tj
2.3868 0 Td
(a)Tj
0.6519 0 Td
(wearable)Tj
-32.9553 -1.3039 Td
(platform)Tj
3.702 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(much)Tj
2.5172 0 Td
(larger)Tj
2.5341 0 Td
(sample)Tj
3.0217 0 Td
(of)Tj
1.0148 0 Td
(PD)Tj
1.5137 0 Td
(patients,)Tj
3.5943 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(focus)Tj
2.33 0 Td
(on)Tj
1.2756 0 Td
(recruitment)Tj
4.9946 0 Td
(success,)Tj
3.3222 0 Td
(attrition)Tj
-34.1572 -1.2983 Td
(rates,)Tj
2.33 0 Td
(user)Tj
1.9049 0 Td
(compliance)Tj
4.8302 0 Td
(and)Tj
1.7291 0 Td
(system)Tj
2.9424 0 Td
(usability.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 338.0598 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 321.0519 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Between)Tj
3.5999 0 Td
(August/2015)Tj
5.3178 0 Td
(and)Tj
1.7291 0 Td
(November/2016,)Tj
6.9222 0 Td
(a)Tj
0.6519 0 Td
(total)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(953)Tj
1.6497 0 Td
(PD)Tj
1.5137 0 Td
(patients)Tj
3.3676 0 Td
(from)Tj
2.2053 0 Td
(two)Tj
1.7121 0 Td
(cohorts)Tj
-31.6854 -1.3039 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7993 0 Td
(304)Tj
1.6498 0 Td
(in)Tj
1.0374 0 Td
(The)Tj
1.7802 0 Td
(Netherlands)Tj
5.1193 0 Td
(\(NL\))Tj
2.1714 0 Td
(and)Tj
1.7347 0 Td
(n)Tj
0.7654 0 Td
(=)Tj
0.7994 0 Td
(649)Tj
1.6497 0 Td
(PD)Tj
1.5137 0 Td
(in)Tj
1.0375 0 Td
(North)Tj
2.6589 0 Td
(America)Tj
3.6453 0 Td
(\(Unites)Tj
3.1918 0 Td
(States)Tj
2.5115 0 Td
(and)Tj
1.7291 0 Td
(Can-)Tj
-34.8999 -1.2982 Td
(adaNAM\))Tj
5.193 0 Td
(participated)Tj
5.0003 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(Parkinson@Hom)Tj
6.9392 0 Td
(e)Tj
0.6406 0 Td
(feasibility)Tj
4.0365 0 Td
(study.)Tj
2.6135 0 Td
(To)Tj
1.338 0 Td
(investigate)Tj
4.4617 0 Td
(the)Tj
1.4683 0 Td
(feasibil-)Tj
-34.1912 -1.2983 Td
(ity)Tj
1.2415 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(technology)Tj
4.6204 0 Td
(in)Tj
1.0375 0 Td
(different)Tj
3.6566 0 Td
(contexts,)Tj
3.7701 0 Td
(both)Tj
2.0579 0 Td
(cohorts)Tj
3.2145 0 Td
(used)Tj
2.0636 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(wearable)Tj
3.7417 0 Td
(platform,)Tj
3.9288 0 Td
(but)Tj
-35.5405 -1.2983 Td
(had)Tj
1.7064 0 Td
(distinct)Tj
3.2145 0 Td
(strategies)Tj
3.9231 0 Td
(for)Tj
1.3833 0 Td
(recruitment,)Tj
5.2214 0 Td
(retention)Tj
3.9061 0 Td
(and)Tj
1.7291 0 Td
(study)Tj
2.3924 0 Td
(period.)Tj
3.0558 0 Td
(These)Tj
2.5681 0 Td
(topics)Tj
2.5966 0 Td
(are)Tj
1.4456 0 Td
(described)Tj
-33.1424 -1.3039 Td
(separately)Tj
4.1839 0 Td
(\(overview)Tj
4.1442 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Table)Tj
2.4377 0 Td
(1)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 230.0031 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.7543 0 Td
(design)Tj
3.1229 0 Td
(and)Tj
1.8661 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 211.9748 212.9952 cm
BT
/F12 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.8481 0 Td
(NL)Tj
1.5024 0 Td
(cohort.)Tj
/F8 1 Tf
3.7984 0 Td
(The)Tj
1.7801 0 Td
(population)Tj
4.5921 0 Td
(and)Tj
1.7291 0 Td
(study)Tj
2.3925 0 Td
(design)Tj
2.8119 0 Td
(applied)Tj
3.1521 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(NL)Tj
1.4967 0 Td
(are)Tj
1.4457 0 Td
(described)Tj
4.0535 0 Td
(in)Tj
1.0375 0 Td
(detail)Tj
-35.3421 -1.2982 Td
(elsewhere.[)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(])Tj
5.9583 0 Td
(In)Tj
1.1112 0 Td
(short,)Tj
2.5115 0 Td
(participants)Tj
4.9549 0 Td
(were)Tj
2.126 0 Td
(recruited)Tj
3.8494 0 Td
(from)Tj
2.211 0 Td
(support)Tj
3.3165 0 Td
(groups,)Tj
3.1975 0 Td
(internet)Tj
3.3959 0 Td
(communi-)Tj
-32.6322 -1.3039 Td
(ties)Tj
1.5703 0 Td
(and)Tj
1.7291 0 Td
(through)Tj
3.447 0 Td
(physiotherapists)Tj
6.7123 0 Td
(specialized)Tj
4.5241 0 Td
(in)Tj
1.0375 0 Td
(treating)Tj
3.3222 0 Td
(PD)Tj
1.5193 0 Td
(patients.)Tj
3.5887 0 Td
(Enrolment)Tj
4.5524 0 Td
(criteria)Tj
-32.0029 -1.2983 Td
(were:)Tj
2.347 0 Td
(\(1\))Tj
/F5 1 Tf
0 Tc
1.3776 0 Td
()Tj
/F8 1 Tf
-0.004 Tc
(30)Tj
1.9389 0 Td
(years)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(age,)Tj
1.7688 0 Td
(\(2\))Tj
1.372 0 Td
(possession)Tj
4.4333 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6577 0 Td
(smartphone)Tj
5.0286 0 Td
(using)Tj
2.3868 0 Td
(an)Tj
1.2018 0 Td
(Android)Tj
3.6567 0 Td
(OS)Tj
1.44 0 Td
(version)Tj
/F5 1 Tf
0 Tc
3.1521 0 Td
()Tj
/F8 1 Tf
-0.004 Tc
0.9921 0 Td
(4.2)Tj
-36.0507 -1.2983 Td
(and)Tj
1.7291 0 Td
(\(3\))Tj
1.3776 0 Td
(self-reported)Tj
5.3291 0 Td
(diagnosis)Tj
3.9571 0 Td
(of)Tj
1.0148 0 Td
(PD.)Tj
1.7405 0 Td
(No)Tj
1.4627 0 Td
(exclusion)Tj
3.9911 0 Td
(criteria)Tj
3.0727 0 Td
(were)Tj
2.126 0 Td
(applied)Tj
3.1521 0 Td
(beyond)Tj
3.1861 0 Td
(enrolment)Tj
-32.1389 -1.2982 Td
(criteria.)Tj
1.1962 -1.3039 Td
(All)Tj
1.4003 0 Td
(enrolled)Tj
3.5149 0 Td
(participants)Tj
4.9549 0 Td
(received)Tj
3.5376 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5342 0 Td
(medical)Tj
3.3618 0 Td
(examination,)Tj
5.4539 0 Td
(based)Tj
2.4774 0 Td
(on)Tj
1.2699 0 Td
(the)Tj
1.474 0 Td
(Parkinson's)Tj
-31.8271 -1.2983 Td
(Progression)Tj
4.9605 0 Td
(Markers)Tj
3.5717 0 Td
(Initiative)Tj
4.2122 0 Td
(\(PPMI\)[)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
5.1024 0 Td
(This)Tj
1.9899 0 Td
(included)Tj
3.7133 0 Td
(the)Tj
1.4684 0 Td
(full)Tj
1.5307 0 Td
(MDS-UPDRS[)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(],)Tj
7.6591 0 Td
(the)Tj
-34.2082 -1.2983 Td
(Montreal)Tj
3.9401 0 Td
(Cognitive)Tj
4.1158 0 Td
(Assessment)Tj
4.8586 0 Td
(\(MoCA\)[)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(],)Tj
5.5048 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.474 0 Td
(Modified)Tj
3.9174 0 Td
(Schwab)Tj
3.2712 0 Td
(and)Tj
1.7348 0 Td
(England)Tj
3.5546 0 Td
(Activi-)Tj
-34.1005 -1.3039 Td
(ties)Tj
1.5703 0 Td
(of)Tj
1.0148 0 Td
(Daily)Tj
2.3584 0 Td
(Living)Tj
2.761 0 Td
(Scale.[)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(])Tj
4.0762 0 Td
(The)Tj
1.7858 0 Td
(medical)Tj
3.3618 0 Td
(examination)Tj
5.2328 0 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.473 0 Td
(by)Tj
1.1792 0 Td
(specially)Tj
3.5943 0 Td
(trained)Tj
-33.1027 -1.2983 Td
(physiotherapists)Tj
6.7123 0 Td
(who)Tj
1.9389 0 Td
(are)Tj
1.4514 0 Td
(members)Tj
3.9458 0 Td
(of)Tj
1.0147 0 Td
(ParkinsonNet[)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(],)Tj
7.6252 0 Td
(a)Tj
0.652 0 Td
(Dutch)Tj
2.7382 0 Td
(network)Tj
3.549 0 Td
(of)Tj
1.0148 0 Td
(health)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 476.0503 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(The)Tj
1.9204 0 Td
(Parkin)Tj
2.778 0 Td
(son@Home)Tj
5.4355 0 Td
(study)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01891)Tj
4.089 0 Td
(61)Tj
0 g
2.0906 0 Td
(December)Tj
4.7622 0 Td
(20,)Tj
1.5875 0 Td
(2017)Tj
32.5561 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(15)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
126.4252 613.6441 m
164.6929 613.6441 l
h
f*
36 602.6457 m
83.622 602.6457 l
h
f*
43.7669 591.6472 m
109.0772 591.6472 l
h
f*
162.9354 580.6488 m
184.0252 580.6488 l
h
f*
36 569.6504 m
108.3402 569.6504 l
h
f*
38.4378 547.6535 m
116.4472 547.6535 l
h
f*
38.4378 536.6551 m
183.2315 536.6551 l
h
f*
77.8961 525.6567 m
140.5417 525.6567 l
h
f*
126.085 514.6583 m
164.3528 514.6583 l
h
f*
36 503.6598 m
138.1606 503.6598 l
h
f*
110.2677 470.6646 m
185.0457 470.6646 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F10 1 Tf
1 TL
-0.025 Tc
0 0 Td
(conclusions)Tj
4.6559 0 Td
(of)Tj
0.9496 0 Td
(this)Tj
1.5662 0 Td
(article)Tj
2.4307 0 Td
(will)Tj
1.4386 0 Td
(be)Tj
1.1197 0 Td
(available)Tj
3.3803 0 Td
(there.)Tj
-15.541 -1.3748 Td
(Interested)Tj
3.926 0 Td
(and)Tj
1.5874 0 Td
(qualified)Tj
3.3165 0 Td
(researchers)Tj
4.5709 0 Td
(will)Tj
1.4386 0 Td
(be)Tj
-14.8394 -1.3748 Td
(required)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(register/apply)Tj
5.2583 0 Td
(and)Tj
1.5874 0 Td
(sign)Tj
1.7858 0 Td
(an)Tj
1.1126 0 Td
(Data)Tj
1.9064 0 Td
(Use)Tj
-15.8883 -1.3748 Td
(Agreement)Tj
4.2732 0 Td
(that)Tj
1.6229 0 Td
(includes)Tj
3.2953 0 Td
(publication)Tj
4.259 0 Td
(and)Tj
1.5946 0 Td
(IP)Tj
-15.045 -1.3748 Td
(policies.)Tj
3.2315 0 Td
(After)Tj
1.9842 0 Td
(registration,)Tj
4.6418 0 Td
(all)Tj
1.0276 0 Td
(enquiries)Tj
3.6 0 Td
(for)Tj
1.2543 0 Td
(data)Tj
-15.7394 -1.3748 Td
(access)Tj
2.7496 0 Td
(will)Tj
1.4386 0 Td
(be)Tj
1.1126 0 Td
(judged)Tj
2.7283 0 Td
(by)Tj
1.1197 0 Td
(the)Tj
1.3678 0 Td
(Michael)Tj
3.0968 0 Td
(J)Tj
0.6378 0 Td
(Fox)Tj
-14.2512 -1.3748 Td
(Foundation)Tj
4.3512 0 Td
(data)Tj
1.7929 0 Td
(sharing)Tj
2.9835 0 Td
(committee)Tj
3.9473 0 Td
(.)Tj
/F9 1 Tf
-13.0749 -2.126 Td
(Funding:)Tj
/F10 1 Tf
3.5716 0 Td
(This)Tj
1.7788 0 Td
(work)Tj
2.0622 0 Td
(was)Tj
1.7008 0 Td
(gratefully)Tj
3.6355 0 Td
(supported)Tj
3.9969 0 Td
(by)Tj
-16.7458 -1.3748 Td
(the)Tj
1.3677 0 Td
(Michael)Tj
3.0969 0 Td
(J)Tj
0.6448 0 Td
(Fox)Tj
1.5378 0 Td
(Foundation)Tj
4.3513 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://w)Tj
3.5575 0 Td
(ww.)Tj
-14.556 -1.3749 Td
(michaeljfox.)Tj
4.4433 0 Td
(org/)Tj
0 g
(\),)Tj
2.2606 0 Td
(Intel)Tj
1.8213 0 Td
(Corporation)Tj
4.5993 0 Td
(\(Tel)Tj
1.6086 0 Td
(Aviv,)Tj
2.0056 0 Td
(Israel)Tj
-16.7387 -1.3748 Td
()Tj
0.83 0.64 0.02 0 k
(https://w)Tj
4.2236 0 Td
(ww.intel.com)Tj
0 g
4.9111 0 Td
(\))Tj
0.5315 0 Td
([grant)Tj
2.459 0 Td
(number)Tj
-12.1252 -1.3748 Td
(10231.01],)Tj
4.2874 0 Td
(the)Tj
1.3748 0 Td
(Stichtin)Tj
2.7851 0 Td
(g)Tj
0.6945 0 Td
(Parkinson)Tj
3.9331 0 Td
(Fonds)Tj
2.4803 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://)Tj
-15.5552 -1.3748 Td
(www.park)Tj
3.763 0 Td
(insonfonds.nl)Tj
5.0244 0 Td
(/)Tj
0 g
(\),)Tj
1.0063 0 Td
(The)Tj
1.5874 0 Td
(Netherlands)Tj
-11.3811 -1.3748 Td
(Organisation)Tj
4.911 0 Td
(for)Tj
1.2614 0 Td
(Health)Tj
2.5725 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(and)Tj
1.5874 0 Td
(Developmen)Tj
4.6417 0 Td
(t)Tj
-18.6662 -1.3748 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://w)Tj
3.5575 0 Td
(ww.zonmw.nl)Tj
5.0953 0 Td
(/en/)Tj
0 g
(\),)Tj
2.1614 0 Td
(Philips)Tj
2.6929 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
-16.5048 -1.3748 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://w)Tj
3.5575 0 Td
(ww.philips.c)Tj
4.5709 0 Td
(om/aw/researc)Tj
5.5205 0 Td
(h/home.htm)Tj
4.5567 0 Td
(l)Tj
0 g
(\),)Tj
-18.2056 -1.3749 Td
(UCB)Tj
1.8567 0 Td
(pharma)Tj
3.0756 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(http://ww)Tj
3.7772 0 Td
(w.ucb.com)Tj
4.1031 0 Td
(/)Tj
0 g
(\),)Tj
1.0064 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
-15.4064 -1.3748 Td
(Movement)Tj
4.1953 0 Td
(Disorders)Tj
3.8268 0 Td
(Society)Tj
2.9268 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://www)Tj
4.8402 0 Td
(.)Tj
-15.7891 -1.3748 Td
(movementdi)Tj
4.6417 0 Td
(sorders.or)Tj
3.8268 0 Td
(g/MDS.htm)Tj
0 g
4.3016 0 Td
(\).)Tj
0.7583 0 Td
(The)Tj
1.5874 0 Td
(author)Tj
-15.1158 -1.3748 Td
(Ana)Tj
1.637 0 Td
(L)Tj
0 Tc
0.4252 0.0213 Td
()Tj
-0.025 Tc
0.2409 -0.0213 Td
(gia)Tj
1.3111 0 Td
(Silva)Tj
1.9771 0 Td
(de)Tj
1.1126 0 Td
(Lima)Tj
2.0623 0 Td
(is)Tj
0.8362 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
-13.5922 -1.3748 Td
(Coordenac)Tj
0 Tc
3.6283 0 Td
()Tj
/F11 1 Tf
-0.025 Tc
0.3614 0 Td
[( m)]TJ
/F10 1 Tf
(o)Tj
1.1127 0 Td
(de)Tj
1.1196 0 Td
(Aperfeic)Tj
0 Tc
2.6575 0 Td
()Tj
-0.025 Tc
0.3615 0 Td
(oamento)Tj
3.4937 0 Td
(de)Tj
1.1126 0 Td
(Pessoal)Tj
3.0969 0 Td
(de)Tj
-16.9442 -1.3748 Td
(N)Tj
0 Tc
0.5385 0 Td
()Tj
-0.025 Tc
0.241 0 Td
(vel)Tj
1.2543 0 Td
(SuperiorCAP)Tj
5.7261 0 Td
(ES)Tj
1.2189 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(http://ww)Tj
3.7772 0 Td
(w.capes.gov)Tj
4.6134 0 Td
(.br/)Tj
0 g
(\))Tj
-17.3694 -1.3748 Td
([grant)Tj
2.459 0 Td
(number)Tj
3.1252 0 Td
(0428-140])Tj
3.9261 0 Td
(.)Tj
0.4464 0 Td
(The)Tj
1.5874 0 Td
(Michael)Tj
3.0969 0 Td
(J)Tj
0.6378 0 Td
(Fox)Tj
-15.2788 -1.3749 Td
(Foundation)Tj
4.3512 0 Td
(was)Tj
1.7008 0 Td
(involved)Tj
3.2953 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3677 0 Td
(data)Tj
1.793 0 Td
(collection,)Tj
-13.3938 -1.3819 Td
(interpretati)Tj
3.9756 0 Td
(on)Tj
1.1693 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(data)Tj
1.7929 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(NAM)Tj
2.0906 0 Td
(cohort)Tj
2.622 0 Td
(and)Tj
-16.2213 -1.3748 Td
(manuscript)Tj
4.4149 0 Td
(revision.)Tj
3.345 0 Td
(The)Tj
1.5945 0 Td
(funder)Tj
2.622 0 Td
(Intel)Tj
1.8142 0 Td
(Corporation)Tj
-13.7906 -1.3748 Td
(provided)Tj
3.4582 0 Td
(support)Tj
3.0969 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(form)Tj
2.0126 0 Td
(of)Tj
0.9496 0 Td
(salaries)Tj
3.0189 0 Td
(for)Tj
1.2544 0 Td
(authors)Tj
-16.0442 -1.3748 Td
(EC)Tj
1.2189 0 Td
(and)Tj
1.5874 0 Td
(MA,)Tj
1.722 0 Td
(participated)Tj
4.5355 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.9055 0 Td
(data)Tj
-15.1158 -1.3748 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5874 0 Td
(writing)Tj
2.7567 0 Td
(the)Tj
1.3678 0 Td
(report.)Tj
2.6787 0 Td
(The)Tj
1.5945 0 Td
(founders)Tj
-13.7268 -1.3748 Td
(Philips)Tj
2.6929 0 Td
(Research)Tj
3.6921 0 Td
(and)Tj
1.5945 0 Td
(UCB)Tj
1.8567 0 Td
(pharma)Tj
3.0686 0 Td
(provided)Tj
-12.9048 -1.3748 Td
(support)Tj
3.0968 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3748 0 Td
(form)Tj
2.0055 0 Td
(of)Tj
0.9496 0 Td
(salaries)Tj
3.0189 0 Td
(for)Tj
1.2615 0 Td
(authors)Tj
3.0401 0 Td
([Philips)Tj
-15.6331 -1.3749 Td
(Research)Tj
3.4724 0 Td
(:)Tj
0.4465 0 Td
(HB;)Tj
1.559 0 Td
(UCB)Tj
1.8568 0 Td
(pharma:)Tj
3.2953 0 Td
(KC,)Tj
1.4952 0 Td
(BB)Tj
1.2686 0 Td
(and)Tj
1.5874 0 Td
(DT])Tj
1.5945 0 Td
(and)Tj
-16.5757 -1.3748 Td
(participate)Tj
3.8338 0 Td
(d)Tj
0.6945 0 Td
(in)Tj
0.8859 0 Td
(writing)Tj
2.7567 0 Td
(the)Tj
1.3677 0 Td
(report,)Tj
2.6859 0 Td
(but)Tj
1.4244 0 Td
(did)Tj
1.3606 0 Td
(not)Tj
1.4174 0 Td
(have)Tj
-16.4269 -1.3748 Td
(any)Tj
1.5378 0 Td
(additiona)Tj
3.3732 0 Td
(l)Tj
0.4181 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2678 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
-14.3646 -1.3748 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5874 0 Td
(analysis)Tj
3.1819 0 Td
(or)Tj
1.0063 0 Td
(decision)Tj
3.2883 0 Td
(to)Tj
0.9496 0 Td
(publish.)Tj
3.1465 0 Td
(The)Tj
-16.9017 -1.3748 Td
(specific)Tj
3.0189 0 Td
(roles)Tj
2.0409 0 Td
(of)Tj
0.9496 0 Td
(these)Tj
2.2111 0 Td
(authors)Tj
3.0473 0 Td
(are)Tj
1.3677 0 Td
(articulated)Tj
4.0536 0 Td
(in)Tj
0.8929 0 Td
(the)Tj
-17.582 -1.3748 Td
(Author)Tj
3.0897 0 Td
(contributi)Tj
3.515 0 Td
(ons)Tj
1.9489 0 Td
(section.)Tj
3.1039 0 Td
(All)Tj
1.1339 0 Td
(other)Tj
2.1473 0 Td
(sponsors)Tj
-14.9387 -1.3748 Td
(did)Tj
1.3606 0 Td
(not)Tj
1.4244 0 Td
(have)Tj
1.9559 0 Td
(any)Tj
1.5378 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2607 0 Td
(design;)Tj
2.9055 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
-14.8324 -1.3749 Td
(collection,)Tj
3.9614 0 Td
(analysis)Tj
3.189 0 Td
(and)Tj
1.5874 0 Td
(interpretati)Tj
3.9756 0 Td
(on)Tj
1.1693 0 Td
(of)Tj
0.9497 0 Td
(the)Tj
1.3677 0 Td
(data;)Tj
2.0197 0 Td
(in)Tj
-18.2198 -1.3748 Td
(the)Tj
1.3677 0 Td
(writing)Tj
2.7567 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(report;)Tj
2.6859 0 Td
(and)Tj
1.5874 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3678 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
-16.2639 -1.3748 Td
(submit)Tj
2.7921 0 Td
(the)Tj
1.3677 0 Td
(paper)Tj
2.3174 0 Td
(for)Tj
1.2543 0 Td
(publication.)Tj
/F9 1 Tf
-7.7315 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(Ana)Tj
1.6371 0 Td
(L)Tj
0 Tc
0.4181 0.0213 Td
()Tj
-0.025 Tc
0.248 -0.0213 Td
(gia)Tj
1.311 0 Td
(Silva)Tj
1.9701 0 Td
(de)Tj
1.1126 0 Td
(Lima)Tj
2.0623 0 Td
(is)Tj
-16.9513 -1.3748 Td
(supported)Tj
3.9897 0 Td
(by)Tj
1.1197 0 Td
(Coordena)Tj
3.5646 0 Td
(c)Tj
0 Tc
0.0638 0 Td
()Tj
/F11 1 Tf
-0.025 Tc
0.3614 0 Td
[( m)]TJ
/F10 1 Tf
(o)Tj
1.1126 0 Td
(de)Tj
1.1197 0 Td
(Aperfeic)Tj
0 Tc
2.6575 0 Td
()Tj
-0.025 Tc
0.3544 0 Td
(oamento)Tj
3.4937 0 Td
(de)Tj
-17.8371 -1.3748 Td
(Pessoal)Tj
3.0968 0 Td
(de)Tj
1.1126 0 Td
(N)Tj
0 Tc
0.5386 0.0212 Td
()Tj
-0.025 Tc
0.2481 -0.0212 Td
(vel)Tj
1.2543 0 Td
(Superior)Tj
4.1457 0 Td
(CAPES)Tj
2.7921 0 Td
([grant)Tj
2.4591 0 Td
(number)Tj
-15.6473 -1.3748 Td
(0428-140])Tj
3.926 0 Td
(.)Tj
0.4464 0 Td
(Tim)Tj
1.637 0 Td
(Hahn)Tj
2.1827 0 Td
(is)Tj
0.8292 0 Td
(supported)Tj
3.9969 0 Td
(by)Tj
1.1126 0 Td
(a)Tj
0.6449 0 Td
(research)Tj
-14.7757 -1.3748 Td
(grant)Tj
2.1543 0 Td
(provide)Tj
2.7567 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
1.1197 0 Td
(the)Tj
1.3677 0 Td
(Stichting)Tj
3.4867 0 Td
(Parkinso)Tj
3.2315 0 Td
(n)Tj
0.6945 0 Td
(Fonds.)Tj
-15.5056 -1.3749 Td
(Luc)Tj
1.5874 0 Td
(JW)Tj
1.4456 0 Td
(Evers)Tj
2.2678 0 Td
(is)Tj
0.8362 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
1.1126 0 Td
(a)Tj
0.6449 0 Td
(research)Tj
3.4158 0 Td
(grant)Tj
-15.3001 -1.3748 Td
(provided)Tj
3.4582 0 Td
(by)Tj
1.1127 0 Td
(UCB)Tj
1.8567 0 Td
(and)Tj
1.5874 0 Td
(Philips)Tj
2.6929 0 Td
(Research.)Tj
3.926 0 Td
(Nienke)Tj
2.7355 0 Td
(M)Tj
-17.3694 -1.3748 Td
(de)Tj
1.1126 0 Td
(Vries)Tj
2.0905 0 Td
(is)Tj
0.8363 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6944 0 Td
(by)Tj
1.1197 0 Td
(a)Tj
0.6378 0 Td
(research)Tj
3.4158 0 Td
(grant)Tj
2.1473 0 Td
(from)Tj
2.0126 0 Td
(The)Tj
-17.3623 -1.3748 Td
(Netherland)Tj
4.0252 0 Td
(s)Tj
0.6449 0 Td
(Organisa)Tj
3.2953 0 Td
(tion)Tj
1.6157 0 Td
(for)Tj
1.2615 0 Td
(Health)Tj
2.5724 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(and)Tj
-17.1072 -1.3748 Td
(Developmen)Tj
4.6417 0 Td
(t.)Tj
0.7016 0 Td
(Eli)Tj
1.0772 0 Td
(Cohen)Tj
2.5866 0 Td
(and)Tj
1.5874 0 Td
(Michal)Tj
2.6788 0 Td
(Afek)Tj
1.8425 0 Td
(are)Tj
-15.1158 -1.3748 Td
(employed)Tj
3.848 0 Td
(by)Tj
1.1197 0 Td
(Intel.)Tj
2.041 0 Td
(This)Tj
1.7787 0 Td
(affiliation)Tj
3.5504 0 Td
(does)Tj
2.0127 0 Td
(not)Tj
1.4173 0 Td
(alter)Tj
1.8213 0 Td
(our)Tj
-17.5891 -1.3748 Td
(adherence)Tj
4.0535 0 Td
(to)Tj
0.9496 0 Td
(PLOS)Tj
2.3316 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
-16.3631 -1.3749 Td
(and)Tj
1.5874 0 Td
(materials.)Tj
3.8339 0 Td
(Lauren)Tj
2.7921 0 Td
(Bataille)Tj
2.8418 0 Td
(and)Tj
1.5874 0 Td
(Margaret)Tj
-12.6426 -1.3748 Td
(Daeschler)Tj
3.8905 0 Td
(are)Tj
1.3678 0 Td
(supported)Tj
3.9898 0 Td
(by)Tj
1.1196 0 Td
(the)Tj
1.3678 0 Td
(Michael)Tj
3.0969 0 Td
(J.)Tj
0.8645 0 Td
(Fox)Tj
-15.6969 -1.3748 Td
(Foundation.)Tj
4.5779 0 Td
(Babak)Tj
2.4804 0 Td
(Boroojerdi,)Tj
4.2874 0 Td
(Kasper)Tj
2.7922 0 Td
(Claes)Tj
ET
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
BT
16.3347 -77.1242 Td
(and)Tj
ET
Q
endstream
endobj
90 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 93 0 R/Contents 94 0 R/TrimBox[0 0 612 792]>>
endobj
91 0 obj
<>
endobj
95 0 obj
<>
endobj
96 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /PI_chars_3 def
/FontType 1 def
/FontBBox {-11 -345 1373 718} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (PI_chars_3) readonly def
/BaseFontName (PI_chars_3) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 58 /colon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤/{zM4aܪ
Q:д'B-r^ܦ6y?rRnu S\U{Oλrs(Βƚ
#d29%s'ƈT1F8&\0Xd&&Zug'VPd]:>u=Q,?#(CV4'..|ӱ5 h
sȀg)fɘ`UXK^>] q\l#5pE"JO}rquáQBr/E7
QW5\GSlu{7ZH(PSf/O;̟w{ɴ}-K hA8!b!U>`#u?Vlnǝ19V+mg'QmA}S Y$í8n uJ ڒx3>[x0Z]
ͩw4M&1+pkC,sr"%q&OjbH{:5$65*S`cr;%s4Oӆe>T+6~pBOD!$c]"~r#nh6$38i˞[~Z}}rHmte9(1½=j{<\ ;? RA?c{Rf1'VԞ_-Lwo]`.l|zjf"![G1BYro˓9[-+z g!}RN+pX!M~HcFh@g%J6B)6!Lq>TX\ݪGF
PiQݓX~Fs;Ölo4/(C?+,ɖxۼ:xU^)
fd,`*>-:}=q$:\Xzcw1Nf(
ZkEeJXfэi@zXc\{a5qKg\5ݩv\Qe%1>OY̗$Y#P[)."^+{"bP]Bt&zeN6
іijDE% 0;̅
~~lfB>u'i4znym%tfԟ^נBTDS6-ghiWk/(r!!˶fc>趕%U