Interactions between metabolic, reward and cognitive processes in appetite control:Implications for novel weight management therapies

Higgs, Suzanne, Spetter, Maartje S, Thomas, Jason M, Rotshtein, Pia, Lee, Michelle, Hallschmid, Manfred and Dourish, Colin T (2017). Interactions between metabolic, reward and cognitive processes in appetite control:Implications for novel weight management therapies. Journal of Psychopharmacology ,

Abstract

Traditional models of appetite control have emphasised the role of parallel homeostatic and hedonic systems, but more recently the distinction between independent homeostatic and hedonic systems has been abandoned in favour of a framework that emphasises the cross talk between the neurochemical substrates of the two systems. In addition, evidence has emerged more recently, that higher level cognitive functions such as learning, memory and attention play an important role in everyday appetite control and that homeostatic signals also play a role in cognition. Here, we review this evidence and present a comprehensive model of the control of appetite that integrates cognitive, homeostatic and reward mechanisms. We discuss the implications of this model for understanding the factors that may contribute to disordered patterns of eating and suggest opportunities for developing more effective treatment approaches for eating disorders and weight management.

Publication DOI: https://doi.org/10.1177/0269881117736917
Divisions: Life & Health Sciences
Life & Health Sciences > Applied Health Research Group
Additional Information: © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Funding: This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) grant number: BB/N008847/1.
Uncontrolled Keywords: Food reward, cognition, metabolic signals, appetite control
Published Date: 2017-10-26
Authors: Higgs, Suzanne
Spetter, Maartje S
Thomas, Jason M ( 0000-0001-7013-8994)
Rotshtein, Pia
Lee, Michelle
Hallschmid, Manfred
Dourish, Colin T

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