Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications

Rana, Karan S., Souza, Lucas Pereira De, Isaacs, Mark A., Raja, Farah N. S., Morrell, Alexander P. and Martin, Richard A (2017). Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications. ACS Biomaterials Science and Engineering, Early ,

Abstract

In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.

Publication DOI: https://doi.org/10.1021/acsbiomaterials.7b00283
Divisions: Engineering & Applied Sciences > Electrical, electronic & power engineering
Engineering & Applied Sciences > Polymer and advanced materials research group
Additional Information: Copyright © 2017 American Chemical Society. This is the accepted author manuscript. Funding: Osteosarcoma UK.
Uncontrolled Keywords: apatite; bioactive glass; bone; cancer; gallium; sarcoma
Full Text Link: http://pubs.acs ... terials.7b00283
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Published Date: 2017-09-22
Published Online Date: 2017-09-22
Authors: Rana, Karan S.
Souza, Lucas Pereira De
Isaacs, Mark A.
Raja, Farah N. S.
Morrell, Alexander P.
Martin, Richard A ( 0000-0002-6013-2334)

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