Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

Gregg, Sharon T., Yuan, Qingchun, Morris, Russell E. and Xiao, Bo (2017). Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications. Materials Today Communications, 12 , pp. 95-105.

Abstract

It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

Publication DOI: https://doi.org/10.1016/j.mtcomm.2017.07.007
Divisions: Engineering & Applied Sciences > Chemical engineering & applied chemistry
Engineering & Applied Sciences > Polymer and advanced materials research group
Engineering & Applied Sciences > European Bioenergy Research Institute (EBRI)
Additional Information: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: EPSRC (EP/M027295/1).
Uncontrolled Keywords: antomicrobials,drug delivery,metal organic framework,nitric oxide,nitric oxide biological function,zeolite,Materials Science(all),Mechanics of Materials,Materials Chemistry
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2017-09
Authors: Gregg, Sharon T.
Yuan, Qingchun
Morris, Russell E.
Xiao, Bo

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