Realistic spatial sampling for MEG beamformer images

Barnes, Gareth R.; Hillebrand, Arjan; Fawcett, Ian P. and Singh, Krish D. (2004). Realistic spatial sampling for MEG beamformer images. Human Brain Mapping, 23 (2), pp. 120-127.


The spatial resolution achievable using magnetoencephalography (MEG) beamformer techniques is inhomogeneous across the brain and is related directly to the amplitude of the underlying electrical sources [Barnes and Hillebrand, Hum Brain Mapp 2003;18:1-12; Gross et al., Proc Natl Acad Sci USA 2001;98:694-699; Van Veen et al., IEEE Trans Biomed Eng 1997;44:867-860; Vrba and Robinson, Proc 12th Int Conf Biomagn 2001]. We set out to examine what an adequate level of spatial sampling of the brain volume is in a realistic situation, and what implications these inhomogeneities have for region-of-interest analysis. As a basis for these calculations, we used a simple retinotopic mapping experiment where stimuli were 17-Hz reversing gratings presented in either left or right visual hemifield. Beamformer weights were calculated based on the covariance of the MEG data in a 0-80 Hz bandwidth. We then estimated volumetric full-width half-maximum (FWHM) maps at a range of sampling levels. We show that approximately 10% of the 1 mm cubic voxels in the occipital volume have a FWHM smoothness of <5 mm, and 80% <10 mm in three subjects. This was despite relatively low mean signal-to-noise ratios (SNR) values of 1.5. We demonstrate how visualization of these FWHM maps can be used to avoid some of the pitfalls implicit in beamformer region-of-interest analysis.

Publication DOI:
Divisions: ?? 13770100JJ ??
Life & Health Sciences > Psychology
Life & Health Sciences > Optometry
Uncontrolled Keywords: FWHM,magnetoencephalography,region-of-interest analysis,SAM,spatial resolution,synthetic aperture magnetometry,Clinical Neurology,Neuroscience(all),Radiological and Ultrasound Technology
Published Date: 2004-10


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