Development of a solid dosage platform for the oral delivery of bilayer vesicles

Wilkhu, Jitinder S., Mcneil, Sarah E., Anderson, David E., Kirchmeier, Marc and Perrie, Yvonne (2017). Development of a solid dosage platform for the oral delivery of bilayer vesicles. European Journal of Pharmaceutical Sciences, in pre ,

Abstract

Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10% mannitol and 10% dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.

Publication DOI: https://doi.org/10.1016/j.ejps.2017.06.014
Divisions: Life & Health Sciences > Pharmacy
Additional Information: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). Funding: BBSRC Industrial Case studentship (BB/G017948/1).
Uncontrolled Keywords: liposomes,oral vaccines,niosomes,vesicles,oral disintegrating tablets,Pharmaceutical Science
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2017-06-12
Authors: Wilkhu, Jitinder S.
Mcneil, Sarah E.
Anderson, David E.
Kirchmeier, Marc
Perrie, Yvonne

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