Correlation of degradation in metronidazole infusion with F0 applied during steam sterilization at 122°C

Barnes, A.R. and Makohon, D.J. (1993). Correlation of degradation in metronidazole infusion with F0 applied during steam sterilization at 122°C. International Journal of Pharmaceutics, 92 (1-3), pp. 233-236.

Abstract

Metronidazole infusion was sterilized in an autoclave at 122°C for different values of F0 up to 65.3 min. Both metronidazole degradation and the Production of nitrite ion correlated with F0. A typical sterilization cycle of approx. 121°C for 15 min. is likely to lead to 1.5-2% loss of metronidazole and the production of 1.5 ppm nitrite. The yield of nitrite was only 3-9% of the metronidazole destroyed.

Publication DOI: https://doi.org/10.1016/0378-5173(93)90285-N
Divisions: Life & Health Sciences > Pharmacy
Uncontrolled Keywords: autoclaving,degradation,F(0),metronidazole,nitrite,sterilization,Pharmaceutical Science
Published Date: 1993-05-03

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