European contribution to the study of ROS:a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)

Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Stella, Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–butuner, Bilge, Dias, Irundika, Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jinjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, Mcbean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Milos, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., di Lisa, Fabio and Daiber, Andreas (2017). European contribution to the study of ROS:a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS). Redox biology, 13 , pp. 94-162.

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Publication DOI: https://doi.org/10.1016/j.redox.2017.05.007
Divisions: Life & Health Sciences
Life & Health Sciences > Psychology
Life & Health Sciences > Biosciences
Life & Health Sciences > Pharmacy
Additional Information: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Funding: COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks.
Uncontrolled Keywords: antioxidants,oxidative stress,reactive nitrogen species,reactive oxygen species,redox signaling,redox therapeutics,Biochemistry,Organic Chemistry
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Related URLs: http://www.scopus.com/inward/record.url?scp=85020032301&partnerID=8YFLogxK (Scopus URL)
Published Date: 2017-10-01
Authors: Egea, Javier
Fabregat, Isabel
Frapart, Yves M.
Ghezzi, Pietro
Görlach, Agnes
Kietzmann, Thomas
Kubaichuk, Kateryna
Knaus, Ulla G.
Lopez, Manuela G.
Olaso-Gonzalez, Gloria
Petry, Andreas
Schulz, Rainer
Vina, Jose
Winyard, Paul
Abbas, Kahina
Ademowo, Stella ( 0000-0003-0232-1935)
Afonso, Catarina B. ( 0000-0003-4828-7146)
Andreadou, Ioanna
Antelmann, Haike
Antunes, Fernando
Aslan, Mutay
Bachschmid, Markus M.
Barbosa, Rui M.
Belousov, Vsevolod
Berndt, Carsten
Bernlohr, David
Bertrán, Esther
Bindoli, Alberto
Bottari, Serge P.
Brito, Paula M.
Carrara, Guia
Casas, Ana I.
Chatzi, Afroditi
Chondrogianni, Niki
Conrad, Marcus
Cooke, Marcus S.
Costa, João G.
Cuadrado, Antonio
My-Chan Dang, Pham
De Smet, Barbara
Debelec–butuner, Bilge
Dias, Irundika ( 0000-0002-6620-8221)
Dunn, Joe Dan
Edson, Amanda J.
El Assar, Mariam
El-Benna, Jamel
Ferdinandy, Péter
Fernandes, Ana S.
Fladmark, Kari E.
Förstermann, Ulrich
Giniatullin, Rashid
Giricz, Zoltán
Görbe, Anikó
Griffiths, Helen ( 0000-0002-2666-2147)
Hampl, Vaclav
Hanf, Alina
Herget, Jan
Hernansanz-Agustín, Pablo
Hillion, Melanie
Huang, Jinjing
Ilikay, Serap
Jansen-Dürr, Pidder
Jaquet, Vincent
Joles, Jaap A.
Kalyanaraman, Balaraman
Kaminskyy, Danylo
Karbaschi, Mahsa
Kleanthous, Marina
Klotz, Lars-Oliver
Korac, Bato
Korkmaz, Kemal Sami
Koziel, Rafal
Kračun, Damir
Krause, Karl-Heinz
Křen, Vladimír
Krieg, Thomas
Laranjinha, João
Lazou, Antigone
Li, Huige
Martínez-Ruiz, Antonio
Matsui, Reiko
Mcbean, Gethin J.
Meredith, Stuart P.
Messens, Joris
Miguel, Verónica
Mikhed, Yuliya
Milisav, Irina
Milković, Lidija
Miranda-Vizuete, Antonio
Mojović, Milos
Monsalve, María
Mouthuy, Pierre-Alexis
Mulvey, John
Münzel, Thomas
Muzykantov, Vladimir
Nguyen, Isabel T.N.
Oelze, Matthias
Oliveira, Nuno G.
Palmeira, Carlos M.
Papaevgeniou, Nikoletta
Pavićević, Aleksandra
Pedre, Brandán
Peyrot, Fabienne
Phylactides, Marios
Pircalabioru, Gratiela G.
Pitt, Andrew R. ( 0000-0003-3619-6503)
Poulsen, Henrik E.
Prieto, Ignacio
Rigobello, Maria Pia
Robledinos-Antón, Natalia
Rodríguez-mañas, Leocadio
Rolo, Anabela P.
Rousset, Francis
Ruskovska, Tatjana
Saraiva, Nuno
Sasson, Shlomo
Schröder, Katrin
Semen, Khrystyna
Seredenina, Tamara
Shakirzyanova, Anastasia
Smith, Geoffrey L.
Soldati, Thierry
Sousa, Bebiana C. ( 0000-0002-1356-6789)
Spickett, Corinne M. ( 0000-0003-4054-9279)
Stancic, Ana
Stasia, Marie José
Steinbrenner, Holger
Stepanić, Višnja
Steven, Sebastian
Tokatlidis, Kostas
Tuncay, Erkan
Turan, Belma
Ursini, Fulvio
Vacek, Jan
Vajnerova, Olga
Valentová, Kateřina
van Breusegem, Frank
Varisli, Lokman
Veal, Elizabeth A.
Yalçın, A. Suha
Yelisyeyeva, Olha
Žarković, Neven
Zatloukalová, Martina
Zielonka, Jacek
Touyz, Rhian M.
Papapetropoulos, Andreas
Grune, Tilman
Lamas, Santiago
Schmidt, Harald H.H.W.
di Lisa, Fabio
Daiber, Andreas

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