Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Stella, Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–butuner, Bilge, Dias, Irundika, Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jinjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, Mcbean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Milos, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., di Lisa, Fabio and Daiber, Andreas (2017). European contribution to the study of ROS:a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS). Redox biology, 13 , pp. 94-162.
Abstract
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
| Publication DOI: | https://doi.org/10.1016/j.redox.2017.05.007 |
|---|---|
| Divisions: | College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences > School of Psychology College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine Aston University (General) |
| Additional Information: | © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Funding: COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. |
| Uncontrolled Keywords: | antioxidants,oxidative stress,reactive nitrogen species,reactive oxygen species,redox signaling,redox therapeutics,Biochemistry,Organic Chemistry |
| Publication ISSN: | 2213-2317 |
| Last Modified: | 18 Dec 2024 08:10 |
| Date Deposited: | 24 May 2017 12:30 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2017-10-01 |
| Published Online Date: | 2017-05-18 |
| Accepted Date: | 2017-05-08 |
| Submitted Date: | 2017-05-05 |
| Authors: |
Egea, Javier
Fabregat, Isabel Frapart, Yves M. Ghezzi, Pietro Görlach, Agnes Kietzmann, Thomas Kubaichuk, Kateryna Knaus, Ulla G. Lopez, Manuela G. Olaso-Gonzalez, Gloria Petry, Andreas Schulz, Rainer Vina, Jose Winyard, Paul Abbas, Kahina Ademowo, Stella ( 
0000-0003-0232-1935)
Afonso, Catarina B. (
0000-0003-4828-7146)
Andreadou, Ioanna Antelmann, Haike Antunes, Fernando Aslan, Mutay Bachschmid, Markus M. Barbosa, Rui M. Belousov, Vsevolod Berndt, Carsten Bernlohr, David Bertrán, Esther Bindoli, Alberto Bottari, Serge P. Brito, Paula M. Carrara, Guia Casas, Ana I. Chatzi, Afroditi Chondrogianni, Niki Conrad, Marcus Cooke, Marcus S. Costa, João G. Cuadrado, Antonio My-Chan Dang, Pham De Smet, Barbara Debelec–butuner, Bilge Dias, Irundika (
0000-0002-6620-8221)
Dunn, Joe Dan Edson, Amanda J. El Assar, Mariam El-Benna, Jamel Ferdinandy, Péter Fernandes, Ana S. Fladmark, Kari E. Förstermann, Ulrich Giniatullin, Rashid Giricz, Zoltán Görbe, Anikó Griffiths, Helen (
0000-0002-2666-2147)
Hampl, Vaclav Hanf, Alina Herget, Jan Hernansanz-Agustín, Pablo Hillion, Melanie Huang, Jinjing Ilikay, Serap Jansen-Dürr, Pidder Jaquet, Vincent Joles, Jaap A. Kalyanaraman, Balaraman Kaminskyy, Danylo Karbaschi, Mahsa Kleanthous, Marina Klotz, Lars-Oliver Korac, Bato Korkmaz, Kemal Sami Koziel, Rafal Kračun, Damir Krause, Karl-Heinz Křen, Vladimír Krieg, Thomas Laranjinha, João Lazou, Antigone Li, Huige Martínez-Ruiz, Antonio Matsui, Reiko Mcbean, Gethin J. Meredith, Stuart P. Messens, Joris Miguel, Verónica Mikhed, Yuliya Milisav, Irina Milković, Lidija Miranda-Vizuete, Antonio Mojović, Milos Monsalve, María Mouthuy, Pierre-Alexis Mulvey, John Münzel, Thomas Muzykantov, Vladimir Nguyen, Isabel T.N. Oelze, Matthias Oliveira, Nuno G. Palmeira, Carlos M. Papaevgeniou, Nikoletta Pavićević, Aleksandra Pedre, Brandán Peyrot, Fabienne Phylactides, Marios Pircalabioru, Gratiela G. Pitt, Andrew R. (
0000-0003-3619-6503)
Poulsen, Henrik E. Prieto, Ignacio Rigobello, Maria Pia Robledinos-Antón, Natalia Rodríguez-mañas, Leocadio Rolo, Anabela P. Rousset, Francis Ruskovska, Tatjana Saraiva, Nuno Sasson, Shlomo Schröder, Katrin Semen, Khrystyna Seredenina, Tamara Shakirzyanova, Anastasia Smith, Geoffrey L. Soldati, Thierry Sousa, Bebiana C. (
0000-0002-1356-6789)
Spickett, Corinne M. (
0000-0003-4054-9279)
Stancic, Ana Stasia, Marie José Steinbrenner, Holger Stepanić, Višnja Steven, Sebastian Tokatlidis, Kostas Tuncay, Erkan Turan, Belma Ursini, Fulvio Vacek, Jan Vajnerova, Olga Valentová, Kateřina van Breusegem, Frank Varisli, Lokman Veal, Elizabeth A. Yalçın, A. Suha Yelisyeyeva, Olha Žarković, Neven Zatloukalová, Martina Zielonka, Jacek Touyz, Rhian M. Papapetropoulos, Andreas Grune, Tilman Lamas, Santiago Schmidt, Harald H.H.W. di Lisa, Fabio Daiber, Andreas |
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