Regulation of G protein-coupled receptors by palmitoylation and cholesterol

Goddard, Alan D. and Watts, Anthony (2012). Regulation of G protein-coupled receptors by palmitoylation and cholesterol. BMC Biology, 10 ,

Abstract

Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.See research article http://www.biomedcentral.com/1471-2121/13/6.

Publication DOI: https://doi.org/10.1186/1741-7007-10-27
Divisions: Life & Health Sciences
Additional Information: © 2012 Goddard and Watts; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Physiology,Biotechnology,Structural Biology,Developmental Biology,Plant Science,Ecology, Evolution, Behavior and Systematics,Cell Biology,Biochemistry, Genetics and Molecular Biology(all),Agricultural and Biological Sciences(all)
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2012-03-19
Authors: Goddard, Alan D. ( 0000-0003-4950-7470)
Watts, Anthony

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