A model for the modular evolution of rna addressing open questions on the origin of life

Briones, Carlos, Stich, Michael and Manrubia, Susanna C. (2010). A model for the modular evolution of rna addressing open questions on the origin of life. Origins of Life and Evolution of Biospheres, 40 (4-5), pp. 429-432.


A main unsolved problem in the RNA world scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers generated by random polymerization of ribonucleotides (Joyce and Orgel 2006). Current estimates establish a minimum size about 165 nt long for such a ribozyme (Johnston et al. 2001), a length three to four times that of the longest RNA oligomers obtained by random polymerization on clay mineral surfaces (Huang and Ferris 2003, 2006). To overcome this gap, we have developed a stepwise model of ligation-based, modular evolution of RNA (Briones et al. 2009) whose main conceptual steps are summarized in Figure 1. This scenario has two main advantages with respect to previous hypotheses put forward for the origin of the RNA world: i) short RNA....

Publication DOI: https://doi.org/10.1007/s11084-010-9213-2
Divisions: Engineering & Applied Sciences > Mathematics
Engineering & Applied Sciences > Non-linearity and complexity research group
Engineering & Applied Sciences > Systems analytics research institute (SARI)
Additional Information: Workshop OQOL’09: Open Questions on the Origins of Life 2009
Uncontrolled Keywords: functional complexity,modular evolution,Rna ligation,Rna replicase,Rna world,hairpin,ribozyme,Ecology, Evolution, Behavior and Systematics,Space and Planetary Science
Full Text Link: http://www.scopus.com/inward/record.url?scp=77954946933&partnerID=8YFLogxK
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Published Date: 2010
Authors: Briones, Carlos
Stich, Michael
Manrubia, Susanna C.


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