The time course of changes in retinal vessel diameter in response to differing durations of flicker light provocation

Heitmar, Rebekka and Summers, Robert J. (2015). The time course of changes in retinal vessel diameter in response to differing durations of flicker light provocation. Investigative Ophthalmology and Visual Science, 56 (12), pp. 7581-7588.

Abstract

Purpose: To determine the response of retinal vessels to differing durations of flicker light (FL) sitmulation. Methods: We recorded retinal arterial and venous vessel dilation to 12.5 Hz flicker light provocation (Retinal Vessel Analyzer, Imedos Systems) of varying duration (5, 7, 10 and 20 seconds) in twelve healthy young individuals (age range 26-45 yrs). All participants underwent a full ocular examination including intraocular pressure and blood pressure measurements. Results: Maximum dilation (MD) did not show a significant dependence on flicker duration in arteries whereas maximum constriction (MC) did. However, in veins MD significantly increased with flicker duration. Approximately 80-90% of MD in arteries is reached within 10 seconds of flicker light stimulation. Conclusions: The vast majority of arterial dilatory capacity is reached within 10 seconds of flicker light stimulation even though venous dilation continues strongly. Since the MC of arteries shows a significant dependence on flicker duration measurements at two different durations can provide more information about the retinal vascular system than at a single flicker duration alone.

Publication DOI: https://doi.org/10.1167/iovs.15-17089
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Psychology
Additional Information: Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc
Uncontrolled Keywords: retinal vessel dilation ,flicker-light stimulation ,flicker duration,Medicine(all),Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Full Text Link:
Related URLs: http://www.scopus.com/inward/record.url?scp=84980438975&partnerID=8YFLogxK (Scopus URL)
Published Date: 2015-11-01
Authors: Heitmar, Rebekka ( 0000-0002-7657-1788)
Summers, Robert J. ( 0000-0003-4857-7354)

Download

[img]

Version: Published Version

| Preview

Export / Share Citation


Statistics

Additional statistics for this record