Designing liposomal adjuvants for the next generation of vaccines

Perrie, Yvonne, Crofts, Fraser, Devitt, Andrew, Griffiths, Helen R, Kastner, Elisabeth and Nadella, Vinod (2016). Designing liposomal adjuvants for the next generation of vaccines. Advanced Drug Delivery Reviews, 99 (Part A), pp. 85-96.

Abstract

Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via a range of administration routes. In the development of liposomal adjuvants, the type of immune response promoted has been linked to their physico-chemical characteristics, with the size and charge of the liposomal particles impacting on liposome biodistribution, exposure in the lymph nodes and recruitment of the innate immune system. The addition of immunostimulatory agents can further potentiate their immunogenic properties. Here, we outline the attributes that should be considered in the design and manufacture of liposomal adjuvants for the delivery of sub-unit and nucleic acid based vaccines.

Publication DOI: https://doi.org/10.1016/j.addr.2015.11.005
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Biosciences
Additional Information: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: EPSRC, Aston University, Novartis and an Nc3R grant
Uncontrolled Keywords: liposomes,vaccines,adjuvants,antigens,delivery systems,microfluidics,QbD,MVA,Pharmaceutical Science
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2016-04-01
Authors: Perrie, Yvonne
Crofts, Fraser
Devitt, Andrew ( 0000-0002-4651-6761)
Griffiths, Helen R ( 0000-0002-2666-2147)
Kastner, Elisabeth
Nadella, Vinod

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