The role of ERK5 in endothelial cell function

Nithianandarajah-Jones, Gopika N., Wilm, Bettina, Goldring, Christopher E.P., Müller, Jürgen and Cross, Michael J. (2014). The role of ERK5 in endothelial cell function. Biochemical Society Transactions, 42 (6), pp. 1584-1589.

Abstract

Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.

Publication DOI: https://doi.org/10.1042/BST20140276
Divisions: Aston Medical School
Additional Information: © The Authors Journal compilation © 2014 Biochemical Society. This verion is not the final peer-reviewed Version of Record.
Uncontrolled Keywords: angiogenesis big MAPK1 (BMK1),endothelial cell,extracellular-signal-regulated kinase 5 (ERK5),mitogen-activated protein kinase (MAPK),signal transduction,Biochemistry,Medicine(all)
Full Text Link: http://www.bioc ... 4.full-text.pdf
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2014-12-01
Authors: Nithianandarajah-Jones, Gopika N.
Wilm, Bettina
Goldring, Christopher E.P.
Müller, Jürgen
Cross, Michael J.

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