Copper complexes as a source of redox active MRI contrast agents

Dunbar, Lynsey, Sowden, Rebecca J., Trotter, Katherine D., Taylor, Michelle K., Smith, David, Kennedy, Alan R., Reglinski, John and Spickett, Corinne M. (2015). Copper complexes as a source of redox active MRI contrast agents. BioMetals, 28 (5), pp. 903-912.

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

Publication DOI: https://doi.org/10.1007/s10534-015-9875-3
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).
Uncontrolled Keywords: copper macrocycles,oxidation–reduction,Redox sensitive contrast agent,imaging,inflammation,Biomaterials,Metals and Alloys,Agricultural and Biological Sciences(all),Biochemistry, Genetics and Molecular Biology(all)
Full Text Link: http://link.spr ... 0534-015-9875-3
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2015
Authors: Dunbar, Lynsey
Sowden, Rebecca J.
Trotter, Katherine D.
Taylor, Michelle K.
Smith, David
Kennedy, Alan R.
Reglinski, John
Spickett, Corinne M. ( 0000-0003-4054-9279)

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Version: Accepted Version


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