Adrenomedullin: receptor and signal transduction

Smith, David M., Coppock, H.A., Withers, D.J., Owji, A.A., Hay, D.L., Choksi, T.P., Chakravarty, P., Legon, S. and Poyner, David R. (2002). Adrenomedullin: receptor and signal transduction. Biochemical Society Transactions, 30 (4), pp. 432-437.

Abstract

Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin calcitonin-gene-related peptide (CGRP) and amylin. Its many biological actions are mediated via CGRP type 1 (CGRP(1)) receptors and by specific adrenomedullin receptors. Although the pharmacology of these receptors is distinct, they are both represented in molecular terms by the type II family G-protein-coupled receptor, calcitonin-receptor-like receptor (CRLR). The specificity here is defined by co-expression of receptor-activity-modifying proteins (RAMPs). CGRP(1) receptors are represented by CRLR and RAMP1, and specific adrenomedullin receptors by CRLR and RAMP2 or 3. Here we discuss how CRLR/RAMP2 relates to adrenomedullin binding, pharmacology and pathophysiology, and how chemical cross-linking of receptor-ligand complexes in tissue relates to that in CRLR/RAMP2-expressing cells. CRLR, like other type II family G-protein-coupled receptors, signals via G(s) and adenylate cyclase activation. We demonstrated that adrenomedullin signalling in cell lines expressing specific adrenomedullin receptors followed this expected pattern.

Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: calcitonin,calcitonin-receptor-like receptor,CRLR,receptor-activity-modifying protein,RAMP,type II G-protein-coupled receptor,GPCR
Full Text Link: http://www.ncbi.nlm.nih.gov/sites/entrez/12196109
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Published Date: 2002-08-28
Authors: Smith, David M.
Coppock, H.A.
Withers, D.J.
Owji, A.A.
Hay, D.L.
Choksi, T.P.
Chakravarty, P.
Legon, S.
Poyner, David R. ( 0000-0003-1590-112X)

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