Antipyretic, analgesic and anti-oxidative activities of Aquilaria crassna leaves extract in rodents

Sattayasai, Jintana, Bantadkit, Jirawat, Aromdee, Chantana, Lattmann, Eric and Airarat, Wanchai (2012). Antipyretic, analgesic and anti-oxidative activities of Aquilaria crassna leaves extract in rodents. Journal of Ayurveda and Integrative Medicine, 3 (4), pp. 175-179.

Abstract

In Thailand, the leaves of Aquilaria crassna have been used traditionally for the treatments of various disorders, but without any scientific analysis. In this study, the antipyretic, analgesic, anti-inflammatory and anti-oxidative properties of A. crassna leaves extract were investigated at a wide dose range in rodents. Experimental animals were treated orally with an aqueous extract of Aquilaria crassna leaves (ACE). They were tested for antipyretic (Baker′s yeast-induced fever in rats), analgesic (hot plate test in mice) and anti-inflammatory (carrageenan-induced paw edema in rats) activities. An anti-oxidative effect of ACE was evaluated by using the DPPH anti-oxidant assay. The results showed that, after 5 hours of yeast injection, 400 and 800 mg/kg ACE significantly reduced the rectal temperature of rats. Mice were found significantly less sensitive to heat at an oral dose of 800 mg/kg ACE, after 60 and 90 min. No anti-inflammatory activity of ACE at an 800 mg/kg dose could be observed in the rat paw assay. An anti-oxidative activity of ACE was observed with an IC 50 value of 47.18 g/ ml. No behavioral or movement change could be observed in mice after oral administration of ACE (800 or 8,000 mg/kg) for seven consecutive days. Interestingly, from the second day of treatment, animals had a significant lower body weight at the 8,000 mg/kg dose of ACE compared to the control. No toxicity was identified and the results of this study state clearly that Aquilaria crassna leaves extracts possess antipyretic, analgesic and anti-oxidative properties without anti-inflammatory activity.

Publication DOI: https://doi.org/10.4103/0975-9476.104427
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: Creative Commons Attribution Non-Commercial Share Alike License
Uncontrolled Keywords: Analgesic,anti-oxidative activity,antipyretic,Aquilaria crassna,rodents,Drug Discovery,Complementary and alternative medicine
Full Text Link: https://www.ncb ... /JAIM-3-175.pdf
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.jaim ... last=Sattayasai (Publisher URL)
Published Date: 2012-10
Authors: Sattayasai, Jintana
Bantadkit, Jirawat
Aromdee, Chantana
Lattmann, Eric
Airarat, Wanchai

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