MHCPred : a server for quantitative prediction of peptide-MHC binding

Guan, Pingping; Doytchinova, Irini A.; Zygouri, Christianna and Flower, Darren R. (2003). MHCPred : a server for quantitative prediction of peptide-MHC binding. Nucleic Acids Research, 31 (13), pp. 3621-3624.

Abstract

Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at large, we have implemented, as a server on the World Wide Web, a partial least squares-base multivariate statistical approach to the quantitative prediction of peptide binding to major histocom-patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive,cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203,HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401and HLA-DRB* 0701).

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