Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation

Parri, H. Rheinalt, Gould, Timothy M. and Crunelli, Vincenzo (2001). Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nature Neuroscience, 4 (8), pp. 803-812.


Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsic [Ca2+]i oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system.

Publication DOI: https://doi.org/10.1038/90507
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: Vimentin,thalamus,astrocytes,biological clocks,calcium channel blockers,calcium signaling,central nervous system,enzyme inhibitors,excitatory amino acid antagonists,GABA antagonists,immunohistochemistry,isoquinolines,lysine,magnesium,membrane potentials,neurons,patch-clamp techniques,tetrodotoxin,N-Methyl-D-Aspartate receptors,synaptic transmission
Full Text Link: http://www.nature.com/neuro/journal/v4/n8/abs/nn0801_803.html
Related URLs:
Published Date: 2001-08-01
Authors: Parri, H. Rheinalt ( 0000-0002-1412-2688)
Gould, Timothy M.
Crunelli, Vincenzo

Export / Share Citation


Additional statistics for this record