Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation

Parri, H. Rheinalt; Gould, Timothy M. and Crunelli, Vincenzo Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nature Neuroscience, 4 (8), pp. 803-812.


Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsic [Ca2+]i oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system.

Publication DOI: https://doi.org/10.1038/90507
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences > Neurosciences research group
Uncontrolled Keywords: Vimentin,thalamus,astrocytes,biological clocks,calcium channel blockers,calcium signaling,central nervous system,enzyme inhibitors,excitatory amino acid antagonists,GABA antagonists,immunohistochemistry,isoquinolines,lysine,magnesium,membrane potentials,neurons,patch-clamp techniques,tetrodotoxin,N-Methyl-D-Aspartate receptors,synaptic transmission


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