The detection of kinin activity in contact lens wear

Mann, Aisling M. and Tighe, Brian J. (2002). The detection of kinin activity in contact lens wear. IN: The detection of kinin activity in contact lens wear. Sullivan, David A.; Stern, Michael E.; Tsubota, Kazuo; Dartt, Darlene A.; Sullivan, Rose M. and Bromberg, B. Britt (eds) Advances in experimental medicine and biology . New York (US): Springer.


Many factors can be, and have been, attributed to the appearance of complications in lens wear, but the greatest is associated with deposition. Reduced acuity, irritation and inflammatory responses are often referred to as adverse reactions arising as a result of deposition. In this study, particular attention was paid to the potential role of adsorbed proteins in activating, mediating and/or stimulating a host immune response, i.e., the hypothesis that the adsorption of certain proteins from the tears and ocular surfaces may actively affect successful lens wear. In particular, the purpose of this study was to investigate the presence of a group of proteins previously undiscovered in the ocular environment. The intention was to target a family of proteins/glycoproteins that have become prominent recently in a variety of inflammatory responses and disorders at many other mucosal associated sites around the body, e.g. in nasal rhinitis and in joint inflammation. The protein cascade in question is the kinin family of inflammatory mediators. The aim was to investigate their presence in the ocular environment, specifically in relation to contact lens wear, and consequently assess the implications of their discovery. High molecular weight kininogen (HMWK), with its central role in kinin responses, was investigated initially as the marker of kinin activity, with subsequent members examined thereafter.

Publication DOI:
Divisions: Engineering & Applied Sciences > Chemical engineering & applied chemistry
Engineering & Applied Sciences > Polymer and advanced materials research group
Additional Information: MEDLINE® is the source for the MeSH terms of this document.
Uncontrolled Keywords: detection ,kinin activity,contact lens wear
Full Text Link:
Related URLs: (Scopus URL)
Published Date: 2002-01-01
Authors: Mann, Aisling M.
Tighe, Brian J.

Export / Share Citation


Additional statistics for this record