The application of counter immunoelectrophoresis (CIE) in ocular protein studies. Part II:kinin activity in the lens wearing eye

Mann, Aisling M. and Tighe, Brian J. (2002). The application of counter immunoelectrophoresis (CIE) in ocular protein studies. Part II:kinin activity in the lens wearing eye. Contact Lens and Anterior Eye, 25 (2), pp. 81-88.

Abstract

The kinin family are a group of bioactive peptides that are closely involved in the modulation of vascular inflammation and local injury. We have demonstrated here, for the first time, a link between kinin activity and contact lens wear. Protein extracts from daily and extended wear etafilcon A, Group IV, Acuvue lenses (Vistakon), were analysed by counter immunoelectrophoresis. In this way, kinin activity associated with contact lens wear was detected. High molecular weight kininogen was used as the marker protein. In contrast, no kinin activity was detected in the non-lens wearing normal eye.

Publication DOI: https://doi.org/10.1016/S1367-0484(02)00004-8
Divisions: Engineering & Applied Sciences > Chemical engineering & applied chemistry
Engineering & Applied Sciences > Polymer and advanced materials research group
Additional Information: Copyright 2008 Elsevier B.V., All rights reserved.
Uncontrolled Keywords: high molecular weight kininogen, Inflammatory mediators,contact lens,tears,counter immunoelectrophoresis
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2002-06
Authors: Mann, Aisling M.
Tighe, Brian J.

Download

Item under embargo.

Export / Share Citation


Statistics

Additional statistics for this record