Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis

Wang, Yang, Lattmann, Eric and Zheng, Qinguo (2003). Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis. Nucleosides, Nucleotides and Nucleic Acids, 22 (5-8), pp. 1247-1249.

Abstract

6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.

Publication DOI: https://doi.org/10.1081/NCN-120022847
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Uncontrolled Keywords: 6-Thioguanosine,modified base,modified RNA,RNA synthesis,Genetics,Biochemistry
Full Text Link: http://www.tand ... 1/NCN-120022847
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2003-09-29
Authors: Wang, Yang
Lattmann, Eric
Zheng, Qinguo

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