Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

Cudmore, Melissa, Ahmad, Shakil, Al-Ani, Bahjat, Fujisawa, Takeshi, Coxall, Heather, Chudasama, Kunal, Devey, Luke R., Wigmore, Stephen J., Abbas, Allyah, Hewett, Peter W. and Ahmed, Asif (2007). Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1. Circulation, 115 (13), pp. 1789-1797.

Abstract

Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their administration to pregnant rats elicits preeclampsia-like symptoms. Heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) exert protective effects against oxidative stimuli. Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release.

Publication DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.660134
Divisions: Life & Health Sciences > Biosciences
Aston Medical School
Life & Health Sciences
Uncontrolled Keywords: endothelium ,endothelium-derived factors ,heme oxygenase-1 ,preeclampsia ,pregnancy ,statins ,angiogenesis
Full Text Link: http://circ.ahajournals.org/content/115/13/1789
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Published Date: 2007-03-26
Authors: Cudmore, Melissa
Ahmad, Shakil ( 0000-0002-9294-0475)
Al-Ani, Bahjat
Fujisawa, Takeshi
Coxall, Heather
Chudasama, Kunal
Devey, Luke R.
Wigmore, Stephen J.
Abbas, Allyah
Hewett, Peter W.
Ahmed, Asif

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