Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

Cudmore, Melissa; Ahmad, Shakil; Al-Ani, Bahjat; Fujisawa, Takeshi; Coxall, Heather; Chudasama, Kunal; Devey, Luke R.; Wigmore, Stephen J.; Abbas, Allyah; Hewett, Peter W. and Ahmed, Asif (2007). Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1. Circulation, 115 (13), pp. 1789-1797.

Abstract

Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their administration to pregnant rats elicits preeclampsia-like symptoms. Heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) exert protective effects against oxidative stimuli. Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release.

Publication DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.660134
Divisions: Life & Health Sciences > Biosciences
Aston Medical School
Life & Health Sciences
Uncontrolled Keywords: endothelium ,endothelium-derived factors ,heme oxygenase-1 ,preeclampsia ,pregnancy ,statins ,angiogenesis
Published Date: 2007-03-26

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