Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Cui, Xianjin; Belo, Salome; Krüger, Dirk; Yan, Yong; de Rosales, Rafael T.M.; Jauregui-Osoro, Maite; Ye, Haitao; Su, Shi; Mathe, Domokos; Kovács, Noémi; Horváth, Ildikó; Semjeni, Mariann; Sunassee, Kavitha; Szigeti, Krisztian; Green, Mark A. and Blower, Philip J. Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials, 35 (22), pp. 5840-5846.

Abstract

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.

Publication DOI: https://doi.org/10.1016/j.biomaterials.2014.04.004
Divisions: Engineering & Applied Sciences > Nanoscience research group
Engineering & Applied Sciences > Electrical, electronic & power engineering
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Additional Information: Creative Commons Attribution 3.0 Unported (CC BY 3.0) Open Access funded by Wellcome Trust. Funding: Centre of Excellence in Medical Engineering funded by the Wellcome Trust; EPSRC under grant number WT088641/Z/09/Z and WT088641/Z/09/Z (in association with the MRC); King’s College London; UCL Comprehensive Cancer Imaging Centre funded by the CRUK (C1519/A10331); and National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’ s College London. The scanning equipment funded by an equipment grant from the Wellcome Trust. Supplementary data: http:// dx.doi.org/10.1016/j.biomaterials.2014.04.004
Uncontrolled Keywords: magnetic nanoparticles,PET,aluminium hydroxide,dual-modal,18F

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