Systematic review investigating the reporting of comorbidities and medication in randomized controlled trials of people with dementia

Smith, Toby, Maidment, Ian, Hebding, Jennifer, Madzima, Tairo, Cheater, Francine, Cross, Jane, Poland, Fiona, White, Jacqueline, Young, John and Fox, Chris (2014). Systematic review investigating the reporting of comorbidities and medication in randomized controlled trials of people with dementia. Age and Ageing, 43 (6), pp. 868-872.

Abstract

Objectives: dementia is a debilitating condition characterised by global loss of cognitive and intellectual functioning, which reduces social and occupational performance. This population frequently presents with medical co-morbidities such as hypertension, cardiovascular disease and diabetes. The CONSORT statement outlines recommended guidance on reporting of participant characteristics in clinical trials. It is, however, unclear how much these are adhered to in trials assessing people with dementia. This paper assesses the reporting of medical co-morbidities and prescribed medications for people with dementia within randomised controlled trial (RCT) reports. Design: a systematic review of the published literature from the databases AMED, CINAHL, MEDLINE, EMBASE and the Cochrane Clinical Trial Registry from 1 January 1997 to 9 January 2014 was undertaken in order to identify RCTs detailing baseline medical co-morbidities and prescribed medications . Eligible studies were appraised using the Critical Appraisal Skills Programme (CASP) RCT appraisal tool, and descriptive statistical analyses were calculated to determine point prevalence. Results: nine trials, including 1474 people with dementia, were identified presenting medical co-morbidity data. These indicated neurological disorders ( prevalence 91%), vascular disorders (prevalence 91%), cardiac disorders ( prevalence 74%) and ischaemic cerebrovascular disease ( prevalence 53%) were most frequently seen. Conclusions: published RCTs poorly report medical co-morbidities and medications for people with dementia. Future trials should include the report of these items to allow interpretation of whether the results are generalisable to frailer older populations.

Publication DOI: https://doi.org/10.1093/ageing/afu100
Divisions: Life & Health Sciences
Life & Health Sciences > Pharmacy
Life & Health Sciences > Applied Health Research Group
Additional Information: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Age and Ageing following peer review. The version of record Smith, T., Maidment, I., Hebding, J., Madzima, T., Cheater, F., Cross, J., ... Fox, C. (2014). Systematic review investigating the reporting of comorbidities and medication in randomized controlled trials of people with dementia. Age and ageing, 43(6), 868-872. is available online at: http://ageing.oxfordjournals.org/content/43/6/868 Supplementary data: available to subscribers in Age and Ageing online.
Uncontrolled Keywords: co-morbidity,cognitive impairment,dementia,older people,systematic review,Ageing,Geriatrics and Gerontology
Full Text Link: http://ageing.o ... ontent/43/6/868
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2014-11-06
Authors: Smith, Toby
Maidment, Ian ( 0000-0003-4152-9704)
Hebding, Jennifer
Madzima, Tairo
Cheater, Francine
Cross, Jane
Poland, Fiona
White, Jacqueline
Young, John
Fox, Chris

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Version: Accepted Version


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