Elevated serum free light chains predict cardiovascular events in type 2 diabetes

Bellary, Srikanth, Faint, Jeffrey M., Assi, Lakhvir K., Hutchison, Colin A., Harding, Stephen J., Raymond, Neil T. and Barnett, Anthony H. (2014). Elevated serum free light chains predict cardiovascular events in type 2 diabetes. Diabetes Care, 37 (7), pp. 2028-2030.


OBJECTIVE: Elevated polyclonal serum immunoglobulin free light chains (FLCs; combined FLCκ+FLCλ [cFLC]) are associated with adverse clinical outcomes and increased mortality; we investigated cFLC and cardiovascular disease (CVD) events in type 2 diabetes. RESEARCH DESIGN AND METHODS: In a cohort study of 352 south Asian patients with type 2 diabetes, serum cFLC, high-sensitivity C-reactive protein (hsCRP), and standard biochemistry were measured. CVD events over 2 years were recorded and assessed usingmultiple logistic regression. RESULTS: cFLC levels were elevated significantly in 29 of 352 (8%) patients with CVD events during 2 years of follow-up (50.7 vs. 42.8mg/L; P = 0.004). Inmultivariate analysis, elevated cFLC (>57.2 mg/L) was associated with CVD outcomes (odds ratio 3.3 [95% CI 1.3-8.2]; P = 0.012) and remained significant after adjusting for age, albumin-to-creatinine ratio, diabetes duration, or treatment. CONCLUSIONS: cFLC elevation is a novel marker for CVD outcomes in type 2 diabetes that warrants further investigation. © 2014 by the American Diabetes Association.

Publication DOI: https://doi.org/10.2337/dc13-2227
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences > Biomedical Sciences research group
Additional Information: © 2014 by the American Diabetes Association.
Uncontrolled Keywords: Internal Medicine,Endocrinology, Diabetes and Metabolism,Advanced and Specialised Nursing,Medicine(all)
Full Text Link: http://www.scopus.com/inward/record.url?scp=84903526436&partnerID=8YFLogxK
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Published Date: 2014-07
Authors: Bellary, Srikanth
Faint, Jeffrey M.
Assi, Lakhvir K.
Hutchison, Colin A.
Harding, Stephen J.
Raymond, Neil T.
Barnett, Anthony H.


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