Oxidised phospholipid regulation of toll-like receptor signalling

Erridge, Clett and Spickett, Corinne M. Oxidised phospholipid regulation of toll-like receptor signalling. Redox report, 12 (1-2), pp. 76-80.


Toll-like receptors (TLRs) serve to initiate inflammatory signalling in response to the detection of conserved microbial molecules or products of host tissue damage. Recent evidence suggests that TLR-signalling plays a considerable role in a number of inflammatory diseases, including atherosclerosis and arthritis. Agents which modulate TLR-signalling are, therefore, receiving interest in terms of their potential to modify inflammatory disease processes. One such family of molecules, the oxidised phospholipids (OxPLs), which are formed as a result of inflammatory events and accumulate at sites of chronic inflammation, have been shown to modulate TLR-signalling in both in vitro and in vivo systems. As the interaction between OxPLs and TLRs may play a significant role in chronic inflammatory disease processes, consideration is given in this review to the potential role of OxPLs in the regulation of TLR-signalling.

Publication DOI: https://doi.org/10.1179/135100007X162121
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Biomedical Sciences research group
Uncontrolled Keywords: toll-like receptor,signalling,oxidised phospholipids,atherosclerosis,arthritis,Internal medicine


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