Leptin decreases apoptosis and alters BCL-2:bax ratio in clonal rodent pancreatic beta-cells

Brown, James E.P. and Dunmore, Simon J. (2007). Leptin decreases apoptosis and alters BCL-2:bax ratio in clonal rodent pancreatic beta-cells. Diabetes/Metabolism Research and Reviews, 23 (6), pp. 497-502.

Abstract

The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators B-cell leukaemia 2 gene product (BCL-2) and BCL2-associated X protein (Bax) in the glucose-responsive BRIN-BD11 beta-cell line.

Publication DOI: https://doi.org/10.1002/dmrr.726
Divisions: Life & Health Sciences > Biosciences
Uncontrolled Keywords: immunoglobulin enhancer binding protein ,leptin ,messenger RNA ,protein Bax ,protein bcl 2
Published Date: 2007-09

Download

Full text not available from this repository.

Export / Share Citation


Statistics

Additional statistics for this record