Systematic screening of compressed ODT excipients : cellulosic versus non-cellulosic

Al-Khattawi, Ali; Iyire, Affiong; Dennison, Tom; Dahmash, Eman; Bailey, Clifford J; Smith, Julian; Rue, Peter and Mohammed, Afzal R. (2014). Systematic screening of compressed ODT excipients : cellulosic versus non-cellulosic. Current drug delivery, 11 , pp. 1-15.

Abstract

The successful development of c ompressed ODTs utilises low compression force s to create a porous structure whereby excipients are added to enhance wicking/swelling action or p rovide strength to the fragile tablet framework. In this work, a systematic investigation comparing materials from two different categories was employed to understand their functionality in binary mixture tablets of the most commonly used diluent mannitol. Cellulose based excipients such as HPC (SSL-SFP), L-HPC (NBD -022) and MCC (Avicel PH -102 ) were compared with non -cellulosic materials such as PEO (POLYOX WSR N -10) and Crospovidone (XL -10). P ure excipient properties were studied using Heckel Plot, compre ssibility profile, SEM and XR PD, w hereas the prepared binary mixture compacts were studied for hardness, disintegration time and friability. Results from our investigation provide insight into differences encountered in product performance of ODT upon inclusion of additional materials. For example, non -cellulosic excipients Polyox and Crospovidone showed higher plasticity (Py values 588 and 450 MPa) in pure form but not in binary mixtures of mannitol . Cellulosic excipients, nonetheless, offer faster disintegration (

Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences > Biosciences
Uncontrolled Keywords: cellulose, compaction, crospovidone, excipients, MCC, mannitol, ODT, POLYOX
Published Date: 2014-03-23

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