Desensitisation of adrenomedullin and CGRP receptors

Hay, Debbie L.; Poyner, David R. and Smith, David M. (2003). Desensitisation of adrenomedullin and CGRP receptors. Regulatory peptides, 112 (1-3), pp. 139-145.

Abstract

Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts. © 2003 Elsevier Science B.V. All rights reserved.

Publication DOI: 10.1016/S0167-0115(03)00032-6
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences > Biomedical Sciences research group
Related URLs:
Uncontrolled Keywords: adrenomedullin,CGRP,CRLR,desensitisation,RAMP,rat-2 fibroblast,Biochemistry,Endocrinology,Physiology,Neuroscience(all)
Published Date: 2003-04-15

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