Skin delivery potency and antitumor activities of temozolomide ester prodrugs

Suppasansatorn, Panassaya, Wang, Guocheng, Conway, Barbara R., Wang, Weidong and Wang, Yongfeng (2006). Skin delivery potency and antitumor activities of temozolomide ester prodrugs. Cancer Letters, 244 (1), pp. 42-52.

Abstract

Clinical trials have shown temozolomide to be an effective agent for treatment of malignant melanoma. In order to investigate its suitability for delivery via the skin, a series of temozolomide esters was synthesized as prodrugs. In vitro assays demonstrated temozolomide, temozolomide acid and the hexyl ester equi-effective against selected cancer cell lines. The susceptibility of the esters to enzyme hydrolysis and their effectiveness for application to the skin were investigated. The esters effectively diffuse through rat skin and the hexyl ester demonstrated profound potency for penetrating through skin. Topical application of 5% (w/v) hexyl ester in DMSO solution on a mouse model demonstrated a significant inhibition of tumor growth. These results suggest that temozolomide esters could be an effective alternative to temozolomide in the treatment of skin cancer. © 2005 Elsevier Ireland Ltd. All rights reserved.

Publication DOI: https://doi.org/10.1016/j.canlet.2005.11.029
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences > Pharmacy
Uncontrolled Keywords: cytotoxicity,prodrugs,skin delivery,temozolomide,temozolomide acid,temozolomide esters,Cancer Research,Molecular Biology,Oncology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2006-11-28
Authors: Suppasansatorn, Panassaya
Wang, Guocheng
Conway, Barbara R.
Wang, Weidong
Wang, Yongfeng

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