Armstrong, Richard A., Myers, D. and Smith, C.U.M.
(1993).
The spatial patterns of plaques and tangles in Alzheimer's disease do not support the 'cascade hypothesis'.
Dementia and Geriatric Cognitive Disorders, 4
(1),
pp. 16-20.
Abstract
In Alzheimer's disease (AD), the 'Cascade hypothesis' proposes that the formation of paired helical filaments (PHF) may be casually linked to the deposition of beta/A4 protein. Hence, there should be a close spatial relationship between senile plaques and cellular neurofibrillary tangles in a local region of the brain. In tissue from 6 AD patients, plaques and tangles occurred in clusters and individual clusters were often regularly spaced along the cortical strip. However, the clusters of plaques and tangles were in phase in only 4/32 cortical tissues examined. Hence, the data were not consistent with the 'Cascade hypothesis' that beta/A4 and PHF are directly linked in AD.
Publication DOI: | https://doi.org/10.1159/000107291 |
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Divisions: | Life & Health Sciences > Optometry Life & Health Sciences > Ophthalmic Research Group Life & Health Sciences |
Uncontrolled Keywords: | Alzheimer's disease,cascade hypothesis,senile plaques,neurofibrillary tangles,spatial patterns |
Full Text Link: |
http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=107291 |
Related URLs: | |
Published Date: | 1993 |
Authors: |
Armstrong, Richard A.
(![]() Myers, D. Smith, C.U.M. |