The size frequency distributions of beta-amyloid deposit subtypes in Alzheimer's disease

Armstrong, Richard A.; Myers, D. and Smith, C.U.M. The size frequency distributions of beta-amyloid deposit subtypes in Alzheimer's disease. Neuroscience Research Communications, 13 (1), pp. 9-17.

Abstract

The size frequency distributions of diffuse, primitive and classic beta/A4 deposits was studied in single sections in the hippocampus, parahippocampal gyrus (PHG) and lateral occipitotemporal gyrus (LOT) in five cases of Alzheimer's disease. In most brain regions, the size distribution of the diffuse deposits was significantly different from that of the primitive and classic deposits. The data suggested that larger diffuse deposits appeared to be converted less often into primitive and classic deposits. Significant differences in the size distribution of primitive deposits were commonly observed between brain regions in which there was no difference in the size distribution of the diffuse deposits. Hence, local brain factors may influence the size of diffuse deposit which can be converted into mature amyloid deposit.

Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Uncontrolled Keywords: Alzheimer's disease,beta/A4 deposits,size class distribution,amyloid formation

Download

Full text not available from this repository.

Export / Share Citation


Statistics

Additional statistics for this record